The snake man's chemical PE log

kingsnake;537495 said:

It’s a lot of information that I have to decide on. Is pge1’s tunica delinking and remodeling effects needed with chemical pe or is simply injecting any vasodilator that grants a strong 2 to 6 hour erection with potentiators like DMSO/PABA to soften the tunica all that’s needed for enlargement?

Once I get my other vaso’s I’ll find out with time.

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probably both. you could even alternate them..

Its the errection time for sure that makes the biggest difference.
Think of the extreme magalophallus cases. They grew after prolonged stress from erections and they didnt supplement with anything.
The key is to not get the tunica toughen up. I think thats also the essence of your tunica article...

IMO..You need to up the intensity, variation or decondition.

Kingsnake, thanks for your continuing extensive research and analysis of chemical Penis Enlargement methods and for keeping the brotherhood informed. As more and more experimenters (chem Penis Enlargement'ers) try various methods, it will be interesting to see which of the methods in Dr. Adam's patent or others prove effective.

Noticed that examples 5 and 6 both indicated that DHT was taken orally, but example 10 indicated subcutaneous injections of DHT. I didn't realize that oral DHT was available, so I presume the reference to oral ingestion was in error especially since in example 6 the DHT was called a "gel".

bigdex28;537504 said:

That study states that PGE1 and PGE0 cause a decrease in the production of collagen. I'm thinking that maybe PGE1 acts not as a collagen delinker but as a protective agent against the overproduction of collagen. When we Penis Enlargement we run the risk of causing too much collagen to be produced which will hinder future gains but by taking PGE1 we can prevent this.

I wondering what is the best way to take PGE1 - before a Penis Enlargement workout or straight after?

If taken before a workout the PGE1 may no longer have it's collagen production reducing effects acting in the penis when you are doing the workout, however,
taking it after a workout may be too late as you penis may already have started it's collagen production in response to the stress of the workout.

I may be experimenting soon with sub cutaneous injections of PGE1 and tb4 into the penis in order to prevent toughening of the outer layers of the tunica. I will probably try this post hanging or I may be able to get away with doing it immediately before hanging.

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Interesting idea. Please update on the effect of subcutaneous injections of PGE1. Are you aware of anyone else trying that?

I'm not aware of anyone else who is trying it. It might not do anything but being a scientist I like to experiment.

Kingsnake have you thought about changing up your workouts? I'm thinking that you really need to attack the tunica - lots of hanging, wet jelqing at low erections and lots of extender use. Maybe cut out all girth based exercises.

Seun;537496 said:

saiyan you need decon break. Try two months off, but keep using the dmso and potaba mix. i think it will help. just my two cent.

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I think cycling girth work is necessary. Gain, cement, break, ensure gains are permanent for 3 months at least. Repeat.

I don't know where you got this information and proof that PGE1 "delinks" the tunica. Do you have references you can post, snake? I've not heard anything about this, didn't see it mentioned anywhere in Dr. Adam's work.

And what do you even mean by "delinking" the tunica? It makes the rubber-like sheet of tendon surrounding the CCs weaker and more pliable? Couldn't tunica stretch be achieved from hanging? You can't hang heavy while on PGE1 so what is the purpose?

If this is the theory, then wouldn't you want to pump immediately after the PGE1 erection subsides to take advantage of this "delinking"?

bigdex28;537504 said:

That study states that PGE1 and PGE0 cause a decrease in the production of collagen. I'm thinking that maybe PGE1 acts not as a collagen delinker but as a protective agent against the overproduction of collagen. When we Penis Enlargement we run the risk of causing too much collagen to be produced which will hinder future gains but by taking PGE1 we can prevent this.

I wondering what is the best way to take PGE1 - before a Penis Enlargement workout or straight after?

If taken before a workout the PGE1 may no longer have it's collagen production reducing effects acting in the penis when you are doing the workout, however,
taking it after a workout may be too late as you penis may already have started it's collagen production in response to the stress of the workout.

I may be experimenting soon with sub cutaneous injections of PGE1 and tb4 into the penis in order to prevent toughening of the outer layers of the tunica. I will probably try this post hanging or I may be able to get away with doing it immediately before hanging.

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I was told by a doctor to keep doses low to avoid inflammation because inflammation leads to collagen production, which leads to tougher to deform tendons etc. Calcium buildup on the tendons. Verapamil is a topical cream which helps block calcium deposits. I was prescribed this after pumping for a few months because the pumpng caused inflammation and the doctor examined my penis and could instantly tell I had a buildup. The verapamil seemed successful, as my dorsal tendon became much less thick and taut in a few months.

I imagine the DMSO essentially does the same thing as Verapamil but not sure if it has any calcium blocking properties.

agent7x6;537519 said:

Interesting idea. Please update on the effect of subcutaneous injections of PGE1. Are you aware of anyone else trying that?

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Do not inject like that. It will cause painful pockets of PGE1 in your penis. I was told this by a doctor. You want it in the CCs and nowhere else. If you aren't in deep enough for the syringe to push down with no resistance, you're doing it wrong.

You people need to seek professional advice on this and stop theorizing. You're going to fuck yourselves up. Why not just try doing actual exercises and using devices properly, daily and committed instead of all this theorizing. Now just using plain old PGE1 isn't enough. Have any of you actually tried just using PGE1 for the 18 months recommended to see the results? No, because that's a lot harder than being a google-search chemist and theorizing. Christ.

Hey Seun. Not sure if a deacon break is needed. I’m thinking what is needed for further progress is for me to find the right dosage to stay above a 75% erection level for 2 to 4 hours. What’s happening right now is pge1 by itself is not keeping me above 75% hardness for over 2 to 4 hours so biomechanical creep can take place as tunica delinking is going on. As soon as I get my other vasodilators to help me get my erection time in, I’m confident that things will improve.

Hey bigdex28. Good find on the info bro.

Hey Syd Kitten. Yeah I know. Example 1 made the biggest gains out of all 10 test subjects. Going from 5 inches to over 9 inches is a huge gain in 18 months time.

Hey dickerschwanz. The thing is I use to pump right after my pge1 erections would subside which is extremely painful do to post pge1 soreness. Now that I’m injecting almost 100 mcgs of pge1 the pain is way too much for me to pump during or right after. Not a chance in hell unless I’m drugged up on strong pain blockers or something. LOL.

I’m am starting to agree with you about chemical Penis Enlargement being the erection time being more important then delinking properties of pge1. If it turns out that largest doses of pge1 isn’t needed and it is indeed the erection time that really matters then other vasodilators can work to achieve a 2 to 5 hour erection without pain.

I could just use 50 mcgs of pge1 which will bring manageable pain then find the right dosage of phentolamine and forsklin to stack with it to bring me up to the 3plus hours of erection at above 75% hardness time mark for better progress.

Hey agent7x6. Yeah examples 5 and 6 did use dht and example 10 was actually getting dht injected into his penis with the vasodilators.

Hey MikeShlort. Here’s a link showing the benefits of pge1 aka prostaglandin.

http://www.ncbi.nlm.nih.gov/puBathmateed/7861547

When I say delinking I mean literally that pge1 unwoven and unravel the cross sectional collagen bonds of the tunica at microscopic levels. This is a process that takes months. As more collagen is unwoven under internal stress which would be the stress of the erection itself and other forms of Penis Enlargement, the tunica will start to give into the stress and enlarge through deformation and mechanical creep. As deformation takes place new cells are generated to fill in the gaps making the tunica sheath that covers the CC and the CS longer which means more blood can engorge the CC and CS before the tunica pressurizes and becomes 100% rigid meaning full erection.

When this happens you have enlargement. Keep repeating this over months to years and the tunica will continue to unweave and remodel giving more and more slack so more blood can engorge the penis before the tunica pressurizes into a full rigid erection. With pge1’s unraveling effects this causes the growth of the tunica through stretch force by expanding the sheath and not the thickness which is what we want because if the thickness of the tunica through cross sectional collagen synthesis builds up then it will make it harder to make gains. AKA TOUGH TUNICA SYNDROME. That’s why the pge1 vasodilator, tb-500 and the DMSO/PABA are used to prevent this.

Here are some quotes in the detailed description of invention in Dr Adam’s patent showing pge1’s aka prostaglandin’s delinking effects. He also talks about the use of relaxin as a potentiator as well.


“0055] Relaxin directly and indirectly triggers a cascade of complex biochemical and cellular effects that can cause general morphological changes to genitalia. Prostaglandins such as prostaglandin F2 alpha and prostaglandin E2 have similar effects. This invention includes the mediators of these cascades as potentiators”.


[0043]A prostaglandin potentiator can be prostaglandin F2 alpha or prostaglandin E2. The potentiator might be relaxin, prostaglandin F2 alpha, or prostaglandin E2, or the biochemical mediators that result in the desired changes in collagen or the connective tissue that produces and remodels collagen and express the effects of relaxin, prostaglandin F2 alpha, or prostaglandin E2.


[0054]The potentiator may be a pharmacological agent or combination of agents that promote cellular processes that result in biological and/or mechanical creep and ultimately induce remodeling of the connective tissues that help define the size and shape of the penis. In addition, an agent which increases solubility of collagen may be used as a potentiator. Agents with very specific mechanisms of action may be used, or other agents with pleomorphic mechanisms of action, such as relaxin or growth hormone which trigger diverse mechanisms to induce growth in the penis may be used. For example, agents may be administered that facilitate the elongation of collagen fibers and accelerate the turnover remodeling rates of collagen through numerous mechanisms. For example, D-penicillamine and dimethyl sulfoxide (DMSO), which promote the elongation of collagen by inhibiting or interfering with inter- and intramolecular collagen cross-linkage may be used. Other agents include, but are not limited to, relaxin, insulin like growth factors, growth hormone, metalloproteinases or metalloproteinases agonists or promoters of collagenase activity, tissue inhibitors of matrix metalloprotenases (TIMPs) other agents that increase collagen solubility, prostaglandins, corticosteroids, or aminobenzoate potassium, a commercial brand being known as Potaba®. Preferred prostaglandins are prostaglandin F2 alpha and prostaglandin E2. Also included are pharmaceutically active sequences, peptidomimetics, or mimetics above the above-listed molecules.


Hey Mikeshlorts. With you saying to just use pge1 for 18 months keep in mind that I’ve been using pge1 now for over 5 months and have reached a point to here I need high dosages to have a good 2 to 4 hour erection if im not injecting close to bedtime. Right now at 90 mcgs it’s not getting me there and the pain is crazy with that much pge1. Not to mention at this point I can’t fit any more pge1 in a 1 CC syringe. I either need to find a source for a higher pge1 concentration or just use other stronger vasodilators to stack with a smaller amount of pge1 to reach 2 to 4 hour erections again like what was done in the patent and what Ronielle did after he reached 500 mcgs of pge1.

Keep in mind that yes there are a lot of theories going around but that’s the point of this thread. What Im doing is experimenting on myself to see what’s the optimal way of aheaving enlargement. So far I’ve gained a quarter inch in midgirth and base girth so this does work even for a vet like me. Right now I’m leaning towards the using what ever safe vasodilator necessary to achieve a nice tunica stretching 2 to 5 hour erection and starting to lean away from the goal of reaching 500 mcgs of PAINFUL pge1 like some of the test subjects did and Ronielle did.

I'm talking to all your followers when I type posts criticizing the theorizers. I realize you've put in your time. I remind everyone that you got your length from 2+ years of hanging and manual Penis Enlargement.

Thanks for the info, great stuff.

Maybe you should just try titrating a 4 hour dose and take it before you go to bed. That's what Dr. Adams suggests.

kingsnake;537598 said:

Hey dickerschwanz. The thing is I use to pump right after my pge1 erections would subside which is extremely painful do to post pge1 soreness. Now that I’m injecting almost 100 mcgs of pge1 the pain is way too much for me to pump during or right after. Not a chance in hell unless I’m drugged up on strong pain blockers or something. LOL.

I’m am starting to agree with you about chemical Penis Enlargement being the erection time being more important then delinking properties of pge1. If it turns out that largest doses of pge1 isn’t needed and it is indeed the erection time that really matters then other vasodilators can work to achieve a 2 to 5 hour erection without pain.

I could just use 50 mcgs of pge1 which will bring manageable pain then find the right dosage of phentolamine and forsklin to stack with it to bring me up to the 3plus hours of erection at above 75% hardness time mark for better progress.

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My subjective observation is, that most heavy gainers did something extreme/intense. Either time or force. sometimes both.
Erect jeqls. multiple sets of clamps all day. same with hanging. then short duration with much force. then the combination.
All of that will be multiplied by some chemicals. But is it the driving factor?
I know from myself, that too tough work will harden the tunica.. and its easier to create a hardened tunica then to soften a tunica(or even unlink)

The pain you feel..is it growing pain or toughening pain? Is the dmso+paba enough to prevent hardening of the tunica?
Cause we know from pe bro sience that someone, who hangs very heavy for a short time, will probably gain some, but will harden, when he hits maximum bearable force ..hindering all further gains..

So you might need some more time in between for low intensity/long time work.
Why not pge1 once a week and 2 days of vasilodators and dmso/paba following..Then extending or pumping.

Only read certain parts but very inspiring!
Any advice where I can research this? Any medical studys on these chemicals I can read about?

Thanks V.

This study was done on fibroblast cells from the tunica of suffers of peyronies:
http://www.ncbi.nlm.nih.gov/puBathmateed/11002396

"Peyronie's disease is a fibromatosis of the tunica albuginea which affects up to 2% of men. Plaque development is believed to result, at least in part, from fibroblast proliferation and excess collagen deposition. Numerous oral and intralesional therapies have been used, including verapamil, colchicine and steroids. The purpose of this study was to investigate the in vitro effects of prostaglandin-E1 (PGE1), verapamil and colchicine on the proliferation rates of fibroblasts derived from Peyronie's disease tissue. Using tissue culture, multiple cell lines comprising fibroblasts from Peyronie's plaque, normal tunica and foreskin were established. Cells of low passage were removed from the parent culture and incubated with varying concentrations of PGE1 (0.1-10 mg/ml), verapamil (10-1000 mg/ml), and colchine (2.5 mg/ml). Proliferation was assessed at 48, 72 and 96 hours using the Vybrant MTT cell proliferation and then compared to control cells. Six plaque lines and 5 normal tunical cell lines were established. These cell lines exhibited excellent linear growth in culture media alone. Co-culture wih PGE1 resulted in no significant inhibition at 0.1 and 1 mg/ml, but a mean inhibition of 60.6+/-11.5% at a concenrtation of 10 mg/ml was noted. Similar inhibition was noted with verapamil at 100 and 1000 mg/ml with a mean inhibition of 65.2+/-10.6%. Colchicine resulted in a mean inhibition of 28% at a concentration of 2.5 mg/ml. Maximum inhibition occurred at 96 hours in all cases. There was no statisitically significant difference in proliferation rates between plaque and normal tunical cell lines. We have developed an in vitro model to assess the effects of biologically active agents on the growth of fibroblasts derived from Peyronie's disease tissue. Our data suggests that PGE1, verapamil, and colchicine inhibit in vitro proliferation of fibroblasts at specific concentrations. Refinement and application of this knowledge may allow the development of useful pharmacologic strategies for men with PD."

Therefore PGE1 may help reduce the production of collagen by fibroblasts in the tunica which would prevent toughening of the tunica. However, injecting into the cc doesn't get the PGE1 to where it is needed.

I have better things to do with my time than injecting my penis and doing Penis Enlargement enlargement exercises. I want a big dick as quickly as possible. Chemical Penis Enlargement shouldn't be this hard.

I would also be careful with injection sites as the injection, itself can cause scar tissue.

I say, once Snake perfects his pain-free chemical recipe, and we get the elongation benefits without all the crap he's had to go through, that we each give Snake the phone number of the first chick we get at post-enlargement!

Hey! This guy is being a guinea pig for all of us.

It's the least we can do...

bigdaddy777;538201 said:

I say, once Snake perfects his pain-free chemical recipe, and we get the elongation benefits without all the crap he's had to go through, that we each give Snake the phone number of the first chick we get at post-enlargement!

Hey! This guy is being a guinea pig for all of us.

It's the least we can do...

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It is important to give much respect to the trials and errors and eventual victories of KingSnakes persistence and tenacity! In all penis enlargement that treads on new territory there will always be a masters of these realms and this is where you find the innovation and advancements that are available.

Most def. It works out well in my favour that by the time I am done hanging, I'll just be able to read all this stuff and see what the verdict is and apply it to my own routine. Although I think just PGE1 and jelqs/pumping will suffice for me. I gain girth easily.

Through my own research, both academic and self-observations, it seems that he is increasing his dosages of the drug far too often to achieve the desired end result. I've gone through many logs of others and have come to the conclusion that far too many users are titrating their dosages up too early and often. What I've seen is a negative return and a great cost to their bank account for no good reason. I've stayed on 6mcg- 8mcg for almost a month and I've not had any tolerance build-up or reduced return. In fact, I've gained in girth; sitting at 6in MEG.

I apologize if it has been posted recently but I may have missed it in this thread. Can someone post a link that KS is buying the DHT cream from?

Keep_Growing;538447 said:

I apologize if it has been posted recently but I may have missed it in this thread. Can someone post a link that KS is buying the DHT cream from?

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http://www.allsaintsclinic.org/testosterone-gel.shtml