DMSO + X to maximize growth - research

Inspired from Kingsnakes trials and my own succes with a DMSO+Nascent Iodine solution I thought that it might make sense to start a thread where we can discuss what could or can work to increase our results with Penis Enlargement.

I will update this post whenever we find out something that works. X means the added substance(s) to the DMSO.

DMSO is an anti inflammatory solvent that carries everything that weights less then itself through the skin.
Many supplements who are ingested are not absorbed that efficient if at all.
Thus DMSO gives the possibility to transport substances that might help with penis enlargement to apply them directly into the skin and the penis.

I myself used DMSO+Nascent iodine in combination to treat scar tissue inside my penis(peyronies)
I grew in 1-2 months 0,2 inches in girth and my former weak erections have now a very good EQ. I feel like the scar tissue on my tunica has softened and allows for more expansion. Its directly related to my treatment with DMSO and Nascent Iodine.

(This stuff is not for starters)
Take care with DMSO as it carries everything lower then its own weight. This means also toxic stuff that comes into contact with dmso on your skin might move inside your body.

DS,

Would you please go into detail regarding the benefits of iodine regarding your scar tissue?

What other benefits does it have?

Know the effect DMSO has to transport substances transdermally, what other substances would you use in regards to Penis Enlargement?

Thanks.

I have some male extra pills I didnt intent to eat as they produce mostly diarreha.
I'm now wondering if it might make sense to open them and dissolve them in DMSO to apply it directly to the dick.
Male extra has as ingridients:
- L-Arginine - Often used with DMSO, so it gets carried transdermal(through the skin). Arginine is directly involved in the collagen cycle
- Pomegrante as ellagic acid - I found some studies not related to the penis were pomegrante was used with DMSO. So it probably is absorbed.
- Zinc as aspertate - found several reports of zinc in combo with dmso but nothing about the aspertate.
- MSM - a form of DMSO itself.
- Cordyceps - Interesting find:
"Further-
more, an isolated extract of Cordyceps sinensis H1-A has
been shown to inhibit apoptosis induced by dimethyl sulfox-
ide (DMSO)"
Apoptosis is cell death. This might be usefull for clamping in dangerous territory ^^(again this is not for newbies)
- omega 3 fatty acid - couldnt find anything if that can be combined.
- L-Methionine
It seems Methionine and DMSO should not be combined:
"For peptides which contain methionine residues the use of DMSO is not recommended because it
leads to methionine sulfoxide formation."
which means- >
"Protein oxidation: Proteins are also targets for free radicals. Oxidative
modification of proteins by reactive oxygen species (ROS) or reactive nitrogen
species (RNS) is implicated in the pathogenesis of various diseases. Oxidative
damage to a specific protein, especially at the active site, can induce a
progressive loss of a particular biochemical function. Several types of ROS-
induced protein modifications have been demonstrated (17), including the loss
of sulfhyryl (SH) groups, formation of carbonyls, disulphide crosslink,
methionine sulfoxide, dityrosine cross-links, nitro tyrosine, and glyoxidation
and lipid peroxidation adducts, among others. Alterations of signal transduction
mechanisms, transport systems, or enzyme activities have been shown (18).
Protein oxidation may be at least in part responsible for atherosclerosis, many
forms of cancer, ischemia-reperfusion injury and may also be associated with
aging "
Tough as MSM(a sort of dmso) is also in the male extra mix Im wondering if this as any health effects... ?
We might ask male extra for that. they shoudl know if msm/dmso + methionine can be combined.
So for now - > No combination of male extra pills with DMSO at least for me.

Powersnake12;494255 said:

DS,

Would you please go into detail regarding the benefits of iodine regarding your scar tissue?

What other benefits does it have?

Know the effect DMSO has to transport substances transdermally, what other substances would you use in regards to Penis Enlargement?

Thanks.

Click to expand...

Well, I cant go into chemcial details. Tough, reading about it a fair bit it is stable info that iodine reduces scar tissue with many first hand reports.
It also reduces fibrosis quote:"(hardening of the tissue due to the deposition of fibrin, similar to the formation of scar tissue)".
I used nascent iodine as it is "atomized" in some form which enables it to bind better to tissue/other cells.

Now I discovered that the scar tissue in my dick is much more pliable and softer. I also think that one plague seperated in two.
I for sure experienced a direct correlation between EQ and the application of dmso+iodine.(the blood couldnt fill properly due to the scar tissue and I guess the scar tissue now "gives" some space)
____

I would theoreticly use every substance that is said to help in growing more dick ^^. Thats what I would like to talk about in this thread
I already did some research above and I hope that some of you guys chime in.
Hopefully in the end we know which substances are safe to use in combination with DMSO, which substances work how and when and if we can combine them in one solution.

dickerschwanz;494261 said:

I have some male extra pills I didnt intent to eat as they produce mostly diarreha.
I'm now wondering if it might make sense to open them and dissolve them in DMSO to apply it directly to the dick.
Male extra has as ingridients:
- L-Arginine - Often used with DMSO, so it gets carried transdermal(through the skin). Arginine is directly involved in the collagen cycle
- Pomegrante as ellagic acid - I found some studies not related to the penis were pomegrante was used with DMSO. So it probably is absorbed.
- Zinc as aspertate - found several reports of zinc in combo with dmso but nothing about the aspertate.
- MSM - a form of DMSO itself.
- Cordyceps - Interesting find:
"Further-
more, an isolated extract of Cordyceps sinensis H1-A has
been shown to inhibit apoptosis induced by dimethyl sulfox-
ide (DMSO)"
Apoptosis is cell death. This might be usefull for clamping in dangerous territory ^^(again this is not for newbies)
- omega 3 fatty acid - couldnt find anything if that can be combined.
- L-Methionine
It seems Methionine and DMSO should not be combined:
"For peptides which contain methionine residues the use of DMSO is not recommended because it
leads to methionine sulfoxide formation."
which means- >
"Protein oxidation: Proteins are also targets for free radicals. Oxidative
modification of proteins by reactive oxygen species (ROS) or reactive nitrogen
species (RNS) is implicated in the pathogenesis of various diseases. Oxidative
damage to a specific protein, especially at the active site, can induce a
progressive loss of a particular biochemical function. Several types of ROS-
induced protein modifications have been demonstrated (17), including the loss
of sulfhyryl (SH) groups, formation of carbonyls, disulphide crosslink,
methionine sulfoxide, dityrosine cross-links, nitro tyrosine, and glyoxidation
and lipid peroxidation adducts, among others. Alterations of signal transduction
mechanisms, transport systems, or enzyme activities have been shown (18).
Protein oxidation may be at least in part responsible for atherosclerosis, many
forms of cancer, ischemia-reperfusion injury and may also be associated with
aging "
Tough as MSM(a sort of dmso) is also in the male extra mix Im wondering if this as any health effects... ?
We might ask male extra for that. they shoudl know if msm/dmso + methionine can be combined.
So for now - > No combination of male extra pills with DMSO at least for me.

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That is something I have never heard of, it is worth a try.

Maximumpills pills supplement:
- Epimedium Saggittum extract (20:1) 360mg
Is aparently a flavonoid and is soluable in DMSO.
- Catuaba Bark Extract (can be solved in dmso - http://www.sciencedirect.com/science/article/pii/S0006899308000346)
- Muira Pauma Extract

Antioxidant and neuroprotective activity

Muira puama is used by Amazonian peoples to prepare traditional remedies for the treatment of various central nervous system conditions, in which free radicals are likely to be implicated. A recent study examined the in vivo antioxidant effect of muira puama extract. Ageing mice (14 months) were treated (i.p.) with saline, DMSO (20%) or muira puama extrct (100mg/kg body weight), and the hippocampus, cerebral cortex, striata, hypothalamus and cerebellum dissected out 60 minutes later to measure antioxidant enzyme activities, free-radical production and damage to macromolecules. Muira puama administration reduced free-radical production in the hypothalamus, lead to significant decrease in lipid peroxidation in the cerebral cortex, striatum and hypothalamus, as well as in the carbonyl content in cerebellum and striatum. In terms of antioxidant enzymes, catalase activity was increased in the cortex, striatum, cerebellum and hippocampus, while glutathione peroxidase activity was increased in the hippocampus. This study suggests that muira puama contains compounds able to improve the cellular antioxidant network efficacy in the brain, ultimately reducing the damage caused by oxidative stress.3

An earlier study examined the neuroprotective properties of an orally administrated ethanol extract of muira puama using hippocampal slices from Wistar rats exposed to oxygen and glucose deprivation followed by re-oxygenation. The ischemic condition significantly impaired cellular viability, and increased free radical generation. In normal tissue, incubation with the muira puama extract (0.6 microg/ml) increased mitochondrial activity by 40%, without affecting free radical levels. In damaged tissue, incubation during and after oxygen and glucose deprivation significantly increased cellular viability. Additionally, at the same concentration, muira puama extract prevented the increase of free radical content induced by oxygen and glucose deprivation. In view of the fact that respiratory chain inhibition and increased generation of free radicals are major consequences of the ischemic injury, this study suggests that muira puama contains useful antioxidant and neuroprotective compounds.4

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http://www.globalnaturalmedicine.com/ptychopetalum-olacoides/
Sounds good!

- Panax Ginseng Extract (soem studies where ti was dissolved in dmso)

we obtained Panax ginseng C.A. Meyer.
This study was designed to investigate the possible collagen production-promoting activities of Panax ginseng

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In conclusion, the data acquired in this study demonstrate
that PGRE can induce the synthesis of Type I collagen

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sounds good.

- Fructus Craetegi - Hawthorn berry(soluable)
- Gingko Biloba Extract

Ginkgo
A recent unpublished study reported that topical application of ginkgo diluted in 1% DMSO had an anti-inflammatory effect in the management of cellulites.

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- Seman Cuscutae(nothing found)
- L -Arginine(already discussed, should work)

It sounds promising. I wil ltry to dissolve a capsule in DMSO and look what happens on a small patch of skin ^^

_______________________
It seems like most of this natural extracts are able to be dissolved in DMSO(remember DMSO is derived from trees)
I think most of the supplements are wasted when eaten and not fully used.
___________

doublelongdaddy;494263 said:

That is something I have never heard of, it is worth a try.

Click to expand...

Yes but dont forget this in the context(male extra into DMSO) you quoted:

- L-Methionine
It seems Methionine and DMSO should not be combined:
"For peptides which contain methionine residues the use of DMSO is not recommended because it
leads to methionine sulfoxide formation."

Click to expand...

Which means as I understand Protein Oxidation. Which could mean:

Protein oxidation may be at least in part responsible for atherosclerosis, many
forms of cancer, ischemia-reperfusion injury and may also be associated with
aging "

Click to expand...

Well this can be said of many things but why take a risk..on the other hand male extra mixes L-Methionine with MSM which is another form of DMSO.

Maybe it(mixing with l-Methionine) also inhibits the transdermal propertys of dmso. Tough I'm no expert on this so people who read all that stuff take it with a grain of salt.
(If you transport unknown stuff via DMSO into your body then its your own fault.)
_________
Next I'm checking out what it does with essential oils cause some essential oils might help too in some way..

DS,

Thanks for the reply.

Do you experience and burning sensations when applying DMSO to your skin?

I have some 70%/30% DMSO/Aloe gel but have yet to try it on my dick.

Powersnake12;494299 said:

DS,

Thanks for the reply.

Do you experience and burning sensations when applying DMSO to your skin?

I have some 70%/30% DMSO/Aloe gel but have yet to try it on my dick.

Click to expand...

Yes the first times even with 70% dmso it burned in combo with iodine. Tough it was bearable. Now my dick kind of used to it.
The 99% with iodine burns for sure. Tough you can take it too.
The dmso aleo gel is top and you wont experience burning I guess as the aloe prevents this. Tough if you have small cuts it might still burn.

I read something prior that a guy put cayenne + dmso on his dick and it burned like hell but after that he got an erection to please his wife which he didnt get normaly. lol

Whats very important with this research is: where does the substance we move into the body is used. This means where is the receptor that the substance is docking onto.
If its in the brain and we apply it to the dick it makes no sense.

It might end up in the bloodstream and at the place where it needs to be at some time but keeping it local might make most sense.

For example L - tyrosin docks in the brain, on what I found with google till now. Tough, I'm not sure what dmso at the head does.
But many people with hair loss problems use dmso on their head daily on the other hand.

Hope some of you guys chime in into the discussion.

Ok excited lol

Mixed some dmso with the Maximumpills pills supplement(I think it came with the sg extender)
3 pills in an eyedropper glas. I filled in the same amount of dmso 99% solution. So half glass pills and the other dmso.
Shaked it and it got really hot.
Clamped 10 minutes while applying the solution. No burn whatsoever.

It did something in my body I think as I feel different like higher temeprature.
Feel good now and seems like my hang is fatter after the 10 minute(light)clamp then otherwise.

Will check for other indicators till tomorrow.

__________
Im not sure how I will proceed with these tests.
Just applying stuff I think is not harmfull and then checking for indicators like EQ, morning wood, size expansion when clamped.

Ok fuck this shit worked. Im sure. Got into the blood stream. Dont know if it reacted directly inside the dick(?). Guess there are some receptors needed.
Anyway I got heat and very intense feeling in my dick. Im also kind of dizzy. I didnt wanted to cum but got too focused on it lol.
And this was approx a 1/5 of a capsule. when I ate 2 of them it didnt had that influence on me.

Next time I run 3 applications. Should be more intense. Will also be interesting if there is a difference when I use it on my arm ^^

dickerschwanz;494313 said:

Whats very important with this research is: where does the substance we move into the body is used. This means where is the receptor that the substance is docking onto.
If its in the brain and we apply it to the dick it makes no sense.

Click to expand...

This is a very important point you have raised, as I was thinking the same. It will be in no use to us or minimal efficiency if the substance we are transporting via DMSO is unable to act as there maybe no receptors in the localized area of the dick. The receptors might be in gastrointestinal tract, pancreas, brain... and there maybe a whole chain of chemical pathway before it reaches the desired effect that we want. I guess doing in depth research on each compound we intend to put in our body is very important, both for safety and efficiency.

Good thread dicker.

About DMSO on the head, I do not think that will be efficient as it will have to penetrate the thick skull before it gets into the soft tissue. For the folks out there with really "thick skull" it would be a waste of time

I have been applying DMSO with Lugol's iodine daily for a year to prevent scaring from my Trimix injections. So far, there has been no scaring, but it is still a little early for scar tissue to start forming.

I also apply it to my glans to reduce discoloration from vacuum applications (pumping and VacExtende). Discoloration definitely dissipates a lot quicker when the DMSO solution is used. I recently started applying Vitanin D oil first.

I have also been applying it to a wart on my wrist which has been reduced in size by about 50%.

makemebig;494452 said:

I also apply it to my glans to reduce discoloration from vacuum applications (pumping and VacExtende). Discoloration definitely dissipates a lot quicker when the DMSO solution is used. I recently started applying Vitanin D oil first.

Click to expand...

Wow, so you have noticed a difference in it's effectiveness discoloration compared to not using it?

doublelongdaddy;494591 said:

Wow, so you have noticed a difference in it's effectiveness discoloration compared to not using it?

Click to expand...

I can definately say that using DMSO with iodine will reduce discoloration.
I think it does it though peeling the skin but also in freeing the iron deposits in the skin in opening the skin barriers.

Serraptase:

Serratiopeptidase breaks down collagen and fibrin. It can help the body "clean out" broken tissue in bones, muscles, tendons, and ligaments. It is especially useful for breaking down fibrin. This helps the body dissolve blood clots. That can be very helpful in healing bruises. And it prevents the formation of scar tissue so that joints retain their range of motion as they heal.

____________
(Topical formulations of serratiopeptidase: Development and pharmacodynamic evaluation)
Only IPM and DMSO were found to be effective in combinatino with seraptase in concentrations over 50%(dmso).
____________
Serrapeptase, like aspirin, is both anti-inflammatory and anticlotting; unlike aspirin, however, serrapeptase can melt through existing fibrous deposits
____________
Serraptase seems like a good thing for Penis Enlargement.

Its an enzyme so it shoudl work, to my understanding, directly on the cells.

Hyaluronic acid

Hyaluronic acid ( HA, also known as hyaluronan) is an essential building block that is naturally present in the human body. (e.g. as a shock absorber in the knees) Among its several functions it is known to stimulate the production of collagen. It is also claimed to improve natural cell repair,
....
"in adult and late gestation fetal wound healing, removal of HA results in fibrotic scarring. Though the exact role of HA in skin scarring is still under investigation, based on all the facts that have been observed, it must be a great contributor to the less fibrous scarring."
"hyaluronic acid content in fetal wounds (these wounds heal without scar formation) is higher than that in adult wounds, which suggests that HA may, at least in part, reduce collagen deposition and therefore lead to reduced scarring"
...
_____
Dmso and hyaluronic acid was tested together in some studies so it can be mixed.

On DMSO and its infleunce on Collagen and smooth muscle:


Prolonged exposure of cultured arterial smooth muscle cells to 1% dimethyl sulfoxide (DMSO) resulted in a remarkable increase in cytoplasmic microtubules and an appearance of bundle-like aggregates of microtubules associated with ribosomes
http://www.ncbi.nlm.nih.gov/puBathmateed/3549003
___________
http://www.cartage.org.lb/en/themes...alcellstructure/Microtubules/Microtubules.htm
Microtubules form part of the cytoskeleton that gives structure and shape to a cell, serve as conveyor belts moving other organelles through the cytoplasm, are the major components of cilia and flagella, and participate in the formation of spindle fibers during cell division (mitosis). Microtubules can function individually or join with other proteins to create larger structures (e.g. cilia). These filaments are composed of linear polymers of tubulin, which are globular proteins, and can increase or decease in length by adding or removing tubulin proteins.

These straight, hollow cylinders are found throughout the cytoplasm of all eukaryotic cells (prokaryotes don't have them) and perform a number of functions.

__________
As I understand it till now, the microtobules are important to the cytoskeleton which also is important for the building of collagen structures.
This could mean that DMSO helps in building new collagen structures. These should be of the healthy kind which we might ensure with adequate enzymes and vitamins.
Tough this is only my amateur understanding.
__
Oner point that worries me a bit is the following quote:
[http://www.ncbi.nlm.nih.gov/puBathmateed/3597282]
"The growth of bovine aortic smooth muscle and endothelial cells was studied after exposure to dimethyl sulfoxide (DMSO) or its major metabolite, dimethyl sulfone (DMSO2). Both compounds caused a dose-dependent inhibition of cell growth as determined by [3H]thymidine incorporation and by counting the number of cells with time of exposure in culture.
..
It is concluded that the growth of smooth muscle cells was similarly inhibited by DMSO and DMSO2, but that smooth muscle cells were more susceptible than endothelial cells to the growth inhibitory effects of these compounds."

-- This states that bovine smooth muscle growth is inhibited under the influence of DMSO...
___
also:
"Dimethyl Sulfoxide Inhibits Tissue Factor Expression, Thrombus Formation, and Vascular Smooth Muscle Cell Activation"
________
In a follow up study:
"Inhibitory effect of dimethyl sulfoxide on the proliferation of cultured arterial smooth muscle cells: relationship to the cytoplasmic microtubules."
..
"Our preliminary study has shown that dimethyl sulfoxide (DMSO) has an inhibitory effect on the proliferation of cultured arterial smooth muscle cells and promotes phenotypic modulation from the synthetic state to the contractile state. In the present study we have examined the effect of DMSO with special attention to relationship between cell growth and cytoplasmic microtubules."
..
" These results suggest that DMSO inhibits DNA synthesis of cultured smooth muscle cells by stabilizing cytoplasmic microtubules."
_________________________
This might mean that using DMSO to expand and heal collagen is very usefull while it isnt for smooth muscle.
This might give some connection to the TGC Theory which states simplified that you have to concentrate on smooth muscle exercises or Tunica exercises to grow the whole dick. (smooth muscle fills the space that the tunica gives)
-------
This study on the other hand sounds good for smooth muscles.
http://www.ncbi.nlm.nih.gov/puBathmateed/2652978
"Synthetic activity of collagen types was examined in cultured arterial smooth muscle cells during modulation from synthetic to contractile phenotype by treatment with dimethyl sulfoxide (DMSO). Smooth muscle cells of rabbit thoracic aorta cultured with a 1% supplement of DMSO for 8 days (DMSO group) predominantly exhibited cellular features of the contractile type with abundant microfilaments and a distinct basement membrane. "
..
"Type analysis of the collagenous protein by SDS-PAGE and subsequent fluorography disclosed a markedly increased ratio of type IV/I collagen*1 and a slightly increased type V/I collagen ratio, as compared with those of controls. A decrease of type III collagen production in DMSO-treated cells probably due to their lower cell density was also recognized"
...(*1 does this mean the type IV or the typoe I did go up?)
___________
http://www.ncbi.nlm.nih.gov/puBathmateed/3440294
-> DMSO has influence in upping type IV collagen which we dont want(we want type 1 or two)
quote:
"Such an enhancement of type IV collagen synthesis appears to be expressed as a result of the phenotypic changes of smooth muscle cells to the contractile state modulated by DMSO."
_________
Well I hope someone can follow my thoughts and has some ideas..

DMSO sure helps but I want to find out when and where it helps best. If it inhibits smooth muscle grow then it might not be usefull for everyday application.

DMSO + smooth muscle research:

http://www.ncbi.nlm.nih.gov/puBathmateed/21967314

Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats.

http://en.wikipedia.org/wiki/Icariin
( The compound is derived from several species of plants in the Epimedium family, which are commonly known as Horny Goat Weed or Yin Yang Huo.[)

->"Untreated diabetic animals had decreased smooth muscle/collagen ratio and endothelial cell content in the corpora cavernosa; treatment with icariin partially attenuating these effects."
"Icariin treatment preserved penile hemodynamics, smooth muscle and endothelial integrity, and neuronal nitric oxide synthase expression in the penis of diabetic rats."