HGH and IGF Chem PE

S

Super

Well-known member
Going to to use HGH and IGF-1, I dont recommend anyone inject into there penis. Dont try this at home:)
 
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This is what my freind told me

"You can inject IGF-1 anywhere on the body sub-q ie. calves, abdominals, shoulder areas, arms,etc. as it will all enter systemic blood circulation shortly after administration.

The irritation/inflamation is also experienced by administration of HGH and is more prevelant in some users than others. It should go away soon, if you're experiencing any at all. Just make sure to rotate your injection sites.

Check with your urologist regarding safety about injecting in the cc and cs in the penis, if you want the maximum amount of proliferation/hyperplasia of cells(growth) in this area."
 
: Biochem Biophys Res Commun. 2001 Feb 9;280(5):1307-15. Related Articles, Links


Insulin-like growth factor-I promotes proliferation and migration of cavernous smooth muscle cells.

Liu X, Lin CS, Spencer EM, Lue TF.

Knuppe Molecular Urology Laboratory, University of California, San Francisco, California 94143-1695, USA.

To better understand the physiology of cavernous smooth muscle cells (CSMC), particularly their regulation by IGF-I, we isolated CSMC from rats of various ages and grew them as cell cultures. CSMC from very young (1 week of age) and very old (28 months of age) rats secreted the least amounts of IGF-I, and those from 16-week-old rats the most. IGF-I stimulated growth of CSMC at an optimal concentration of 12.5 ng/ml. At this concentration, CSMC from 11-week-old rats showed the highest growth rate and CSMC from 28-month-old rats showed the lowest. The optimal IGF-I concentration for migration of CSMC was 10 ng/ml. At this concentration, CSMC from 4-week-old rats showed the highest migratory rate and CSMC from 28-month-old rats showed the lowest. IGF-I also stimulated VEGF secretion from CSMC at an optimal concentration of 10 ng/ml. At this concentration, CSMC from 16-week-old rats secreted VEGF the most and CSMC from 28-month-old rats secreted the least. The expression levels of IGF-IR paralleled the IGF-I-regulated growth rates of these cells. Expression of IGF-IR was identified in the cavernous smooth muscle and the urethra epithelium of the penis.
 
1: Eur J Endocrinol. 1998 Feb;138(2):176-80. Related Articles, Links


Effect of insulin-like growth factor-I treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance).

Laron Z, Klinger B.

Endocrine and Diabetes Research Unit, Schneider Children's Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel.

Serum gonadotrophins. androgens, insulin and insulin-like growth factor-I (IGF-I) were determined before and during long-term treatment with recombinant IGF-I of seven males with Laron syndrome, and the changes correlated with changes in testicular volume and penile size. The subjects were four boys below the age of 5, two boys aged 10 and 14 but prepubertal and one 28-year-old fully sexually developed adult. IGF-I was administered by a once daily subcutaneous injection of 150 microg/kg per day to the boys and 120 microg/kg per day to the adult patient. In the very young boys no change in serum gonadotrophins, androgens, gonads or genitals was registered. In the two older boys and the adult patient, there was a progressive rise in luteinizing hormone, follicle-stimulating hormone and testosterone. Concomitantly, there was an increase in size of the testes and penile length. The two boys started puberty. As very high serum IGF-I levels were registered in the adult patient, the daily dose was progressively decreased to 70 microg/kg per day. Stopping the IGF-I administration in this patient, according to the protocol, led to a return to pretreatment serum levels and testicular and penile size. This report shows for the first time a direct effect of IGF-I on sex hormones and sex organs in the male.
 
Androl. 1993 Mar-Apr;14(2):73-8. Related Articles, Links


Insulin-like growth factor 1, but not growth hormone, has in vitro proliferative effects on neonatal foreskin fibroblasts without affecting 5-alpha-reductase or androgen receptor activity.

Dykstra KD, Payne AM, Abdelrahim M, Francis GL.

Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Clinical observation of patients with congenital growth hormone (GH) deficiency and Laron-type dwarfism suggests that factors such as GH or insulin-like growth factor 1 (IGF-1) might in addition to androgens, be needed for normal phallic growth. We speculated GH or IGF-1 might have direct actions on genital tissues and performed the present study to evaluate the in vitro effects of GH and IGF-1 on cultured neonatal foreskin fibroblasts. Cells derived from foreskins of normal newborns were studied between cell passages 6 and 15. Serum-free media with and without 100 ng/ml GH, IGF-1, or both were added 24 hours prior to and at the time of study. To determine the activity of 5-alpha-reductase (5-alpha-R), 3H-testosterone (T: 2 nM) was added, and 5-alpha-R activity was calculated as femtomoles 3H-dihydrotestosterone and 3H-androstanediol produced/microgram DNA/hour. Androgen receptor (AR) binding was determined by the addition of 3H-dihydrotestosterone (dHT; 0.03125-0.5 nM) in the presence and absence of a 200-fold excess of unlabeled dHT. Specific binding was used in Scatchard analysis for determination of AR number (Bmax) and binding affinity (Kd). The rate of DNA synthesis was determined by incorporation of 3H-thymidine (3H-Thy) into trichloroacetic acid-insoluble material. DNA and protein content were determined on cell lysates. IGF-1, but not GH, had proliferative effects (significant increases in the rate of 3H-Thy incorporation, DNA, and protein content) but no effect on 5-alpha-R activity, Bmax or Kd.(ABSTRACT TRUNCATED AT 250 WORDS)
 
I am debating whether ot not to just inject in my penis at 10mcg's a day for a while or stick with doing it in my calves as well at 30mcg's a day
 
So, reading those studies it said that pretreatment size returned to the penis once IGF injections were halted. Also, how long does it take for a physical difference to take effect? Keep us posted!!!
 
Fascinating stuff. So whatever changes you incur, according to the study, will be temporary.

Subscribing to this thread for sure.
 
davidwh said:
Fascinating stuff. So whatever changes you incur, according to the study, will be temporary.

Subscribing to this thread for sure.
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Mabey not, those people did not do Penis Enlargement, and IGF growth is permanant
 
fallen_one23 said:
what about the bubble thing, getting to your heart and killing you? is all IGF injections or are some oral?
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Good question.

Yes, a bolus (bubble) would kill you. But you can avoid that by being careful.

Supra quoted his friend saying "Check with your urologist regarding safety about injecting in the cc and cs in the penis, if you want the maximum amount of proliferation/hyperplasia of cells(growth) in this area."

Good advice.

Supra, did you inject into the corpus cavernosum (CC) this time, or just subcutaneously?

In general, you want to make sure your injection has no air bubbles and that you do not inject into a vein. To prevent air bubbles, you have to inspect the syringe after you draw the contents from the vial, and if there are any bubbles, squirt them out so that there are none left, then do the injection.
Flicking a finger against the syringe with the needle pointed up can help
gather any bubbles at the top so you can "squeeze" them out.

Avoiding veins is not so easy (well, if you penis is vascular and veiny, it should be easy to avoid the obvious ones on the surface), but if you have a doctor or nurse show you how, or you study the diagrams Supra linked to well, you should be ok. But, it is risky. If you have a bodybuilder friend that shoots AS, he could also be a resource to check with first (might be easier to ask than a doctor or nurse, who will wonder why you're asking).

One way to make sure you did not enter a vein, is to first, after you insert the needle, *gently* try to pull out on the syringe. If you hit a vein, blood would easily enter the syringe. If you did not hit a vein, the vacuum that exists would make it hard to pull the syringe out (which is what you want).

Bgrand
(disclaimer: I'm not a doctor, and this is not medical advice)
 
Avoiding bubbles is not that big of a deal. Not as hard to do as it sounds like...or as difficult as the faint of heart types will tell you. Even with oil based injectibles like steriods (I did 3 cycles in the Marines), all you have to do it draw the fluid into the syringe, turn it needle to the sky, holding it up to some light and tap any bubbles to the top...waiting a minute or so for them to rise and then squirt out the first few drops through the needle to rid the syringe of bubbles.

More of a concern than anything...(even Yikes, airbubbles) is the sterility of the materials used. Use a new needle every time.
 
bg brand. What your talking about there is called 'aspiration' its very important to do this when injecting. just pull the plunger up on the syrynge. If blood enters the chamber thats bad news. withdraw and try another site. If you see bubbles entering the syrynge you good to go. hope that helps
 
I find this very interesting. I have just never injected anything before in my life and it sounds scary. I mean I'm not scared of needles or anything,but all this bubble and death talk, wtf. Also, can you inject it somewhere besides your dick and will it still work or is this a site specific?
 
If you want the maximum amount of proliferation/hyperplasia of cells(growth) in this area, that is what IGF does were ever you shoot it it casues massive growth there, but still goes to the rest of the body as well
 
bigbutnottoo said:
I find this very interesting. I have just never injected anything before in my life and it sounds scary. I mean I'm not scared of needles or anything,but all this bubble and death talk, wtf. Also, can you inject it somewhere besides your dick and will it still work or is this a site specific?
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It doesn't have to be scary. Just good to be careful. The comment about using a new needle every stick is also a good one, and also good to use an alcohol swab to rub the injection site clean beforehand as well. No one wants an infected penis, right?
 
bgrand said:
It doesn't have to be scary. Just good to be careful. The comment about using a new needle every stick is also a good one, and also good to use an alcohol swab to rub the injection site clean beforehand as well. No one wants an infected penis, right?
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I take all of these steps
 
Damm Supra, Be careful! It's very important that you are injecting properly because if you keep fucking up and shooting in the same place...especially with bad form (for lack of a better term), you will get some scar tissue build-up that can turn into peyroneis disease and cause ED. Also, you'll wan't to change places regurlarly because if you're injecting into the right CC-"balloon", for instance, it could could grow much bigger than the other, so it's important that you alternate side's.

Good luck and be careful!
 
I am changing places every time, I tried calling you today, no answer, I wanted to talk to you about this, get on AIM
 
SLICEDBEEF said:
Damm Supra, Be careful! It's very important that you are injecting properly because if you keep fucking up and shooting in the same place...especially with bad form (for lack of a better term), you will get some scar tissue build-up that can turn into peyroneis disease and cause ED. Also, you'll wan't to change places regurlarly because if you're injecting into the right CC-"balloon", for instance, it could could grow much bigger than the other, so it's important that you alternate side's.

Good luck and be careful!
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I am sure you knew this was comming man, you know I am a crazy marine
 
You guys call me a pussy but I would stop this, like right now! When I read this thread and realized what was going on I actually got dizzy.. I think this type of activity, at the very least, should be done by a medical doctor.. I'd venture to say that it shouldn't be done at all.. I mean look what DLD did with motivation and his bare hands...

Supra, buddy... You've made good gains, brought the "ring of power" device to light... Stop this maddness before something bad happens.. I know Rome wasn't built in a day and ya got to break a few eggs to make breakfast but I honestly feel like *if* you are doing this kind of thing, you shouldn't be.. At the very least a medical type of person *doctor* should be doing this but something tells me you would be hard pressed to find one willing to do it...

You are doing good man, there is no need to go down this dangerous path..

Treepapaniner
AKA
Regularwhiteguy
 
Its nice to see you here Regularwhiteguy, why dont you go by the same name here as you do at Penis EnlargementF?
 
I agree with Treepapaniner/Regularwhiteguy...this is dangerous and bizare. Supra, don't keep doing this and please, please don't anyone else do it. Something bad, awful could happen. You could maim yourself and end up with a crippled penis. More than that, you could have a reaction and die. This is dangerous stuff. GS
 
German Stallion said:
I agree with Treepapaniner/Regularwhiteguy...this is dangerous and bizare. Supra, don't keep doing this and please, please don't anyone else do it. Something bad, awful could happen. You could maim yourself and end up with a crippled penis. More than that, you could have a reaction and die. This is dangerous stuff. GS
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I second that, no one do this, I am juset a crazy SOB, DO NOT TRY THIS, unless you really want to
 
Supra said:
I second that, no one do this, I am juset a crazy SOB, DO NOT TRY THIS, unless you really want to
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Supra, is your IGF suspended in BA and if so did you dilute the 10 mcg with plenty of Bac water before injecting? I'm wondering because if you injected the straight BA then that will for sure cause tissue necrosis. <:(
 
NeedMoreSize said:
Supra, is your IGF suspended in BA and if so did you dilute the 10 mcg with plenty of Bac water before injecting? I'm wondering because if you injected the straight BA then that will for sure cause tissue necrosis. <:(
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First it is in BA, second you dont use Bac water and it detroyes the IGF
 
Its nice to see you here Regularwhiteguy, why dont you go by the same name here as you do at Penis EnlargementF?
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So what are you saying Supra!?!? ................... us Regularblackguy's are not wanted here?!?!

Peace rofl
 
check out those instructions...

i normally dont mind needles TOO much, but... needles, penis... my stomach don't feel so good!


dopefish.
 
Supra said:
"Stopping the IGF-I administration in this patient, according to the protocol, led to a return to pretreatment serum levels and testicular and penile size."
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Supra said:
...those people did not do Penis Enlargement, and IGF growth is permanant
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So if IGF growth is permanent, then the results of the quoted study of the 28-year old male should have been permanent. Of course, they didn't do Penis Enlargement but we might draw a parallell to the use of IGF-1 for bodybuilding purposes; there is no permanent tissue growth there either, or should I say, the permanent tissue growth that I've read about has all been detrimental to overall health (enlargement of organs and such).
 
ebon00 said:
So if IGF growth is permanent, then the results of the quoted study of the 28-year old male should have been permanent. Of course, they didn't do Penis Enlargement but we might draw a parallell to the use of IGF-1 for bodybuilding purposes; there is no permanent tissue growth there either, or should I say, the permanent tissue growth that I've read about has all been detrimental to overall health (enlargement of organs and such).
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HGH and IGF growth is permanant. Onec hyperplasia takes place, it is irreversable
 
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Do Not Use Bac Water With Igf!!!! Only Benzyl Alcohol! I cant say it enough!

Bac water will ruin your IGF
 
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2nd day second shot

10mcg's in the penis

10mcg's in each calve

30mcg's total

Plus I took Cialis 25mg
 
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