Supplement Hormone RELAXIN

I recently had the idea of supplementing the hormone Relaxin to experiment with the added elasticity and degradation it has on tendons, Ligaments, and collagen in general. I'm not sure about doing this because it will cause all collagen in the body to become weaker for a period of time and that could lead to a weak back, sprain ankles and weak knees. But the added elasticity and weakness of the collagen would allow for a much easier and faster lengthening and thickening of the penis. Men naturally produce relaxin in the Seminal vesicles but only a fraction of what a women produces, That's why women are so flexible and get hurt easier. This is just a theory I've been thinking about and I believe it could have get benefit but at a cost, After taking the supplement which the synthetic lab made version cost around $80.00 a bottle your body's collagen would be weakened for a period of 6-months to a year and the possibility for injury in sports and exercise would increase substantially. Anyone ever think of this and if so what were your finding's Positive/negative that I haven't mentioned.

I also believe that smoking lowers total Relaxin out-put as well as increasing Fibroblast function so smoking could have a slowing effect on potential gains. The softer and more flexibly the tissue the easier and larger the expansion, Potentially smoking could harden/thicken the tissue making Plastic deformation easier but total expansion harder. So my idea is being that I'm a long time smoker up to a pack a day I will quit and see if that potentially helps my gains. Work outs should also help gains in there ability to increase the Relaxin level, This is all a theory but I'll give it a try and let everyone know my progress compared to my current progress of between 1/16-1/8" a week.

At least part of the smoking-related effect you mentioned is due to increasing oxidant (free-radical) load in the body. Increased oxidant stress in the body causes oxidation of the thiol moiety of cystiene (an amino acid) residues on collagen. This causes thiol cross linking between collagen fibers, which reduces their pliancy.

Stopping smoking was a great idea. Now, make sure that you avoid other sources of free-radicals and eat plenty of fresh fruits and vegetables, particularly leafy greens like spinach, which are excellent dietary sources of anti-oxidants. If you choose to supplement with anti-oxidants, I suggest alpha-lipoic acid or, if you can get it, lipoamide. These are more potent reductants (anti-oxidants) than vitamin C (ascorbic acid) or vitamin E (alpha-Tocopherol), but these latter two work well also. Some warnings about dosing, don't take more than about 1 gram (1000 mg) of vitamin C, since it doesn't add any marked benefit and can cause diarrhea at 2-4+ gram doses. And, megadoses of vitamin E, greater than 400 I.U. per day, has been shown to be a pro-oxidant. The jury is still out on this, but why risk it. One other thing about vitamin E: it is fat soluble, so taking megadoses results in storage of the excess in body fat, which can lead to toxicity.

Cheers!

Shouldn't you be stretching right now!

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Dickleaker;412683 said:

Shouldn't you be stretching right now!

Click to expand...

What is up with this post here it is not from this thread. I thought this was going to be about relaxing!

Priapologist;160133 said:

Some warnings about dosing, don't take more than about 1 gram (1000 mg) of vitamin C, since it doesn't add any marked benefit and can cause diarrhea at 2-4+ gram doses.

Click to expand...

Here's a couple study's about Vitamin C. It is very effective at reducing serum cortisol concentrations (stress hormone). When your cortisol is raised your immune system is suppressed. In the morning our bodies release cortisol to ramp up our adrenals so we have energy to go about our day. I take 3grams in the morning, and 1-2grams post workout.

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Int J Sports Physiol Perform. 2008 Dec;3(4):516-30.
Vitamin C supplementation and salivary immune function following exercise-heat stress.

Carrillo AE, Murphy RJ, Cheung SS.

Environmental Ergonomics Laboratory, School of Health and Human Performance, Dalhousie University, Halifax, NS, Canada.
Abstract

PURPOSE: Prolonged physical exertion and environmental heat stress may elicit postexercise depression of immune cell function, increasing upper respiratory tract infection (URTI) susceptibility. We investigated the effects of acute and short-term vitamin C (VC) compared with placebo (PL) supplementation on URTI susceptibility, salivary immunoglobulin A (s-IgA), and cortisol responses in healthy individuals following prolonged exercise-heat stress.

METHODS: Twelve participants were randomized into the VC or PL group in a double-blind design. For 12 days, participants consumed 3x500 mg tablets of VC or PL per day, with testing completed at baseline, then following acute (1 d) and short-term (8 d) supplementation. Participants performed 120.1+/-49.6 min of cycling at 54+/-6% VO2max in a hot (34.8+/-1.0 degrees C and 13+/-3% relative humidity) environment, with saliva samples collected at pre-, post-, and 72 h postexercise. Health logs specifying URTI symptoms were completed for 7 days postexercise.

RESULTS: A 2x3x3 mixed ANOVA with a post hoc Bonferroni correction factor revealed a significant linear trend in postexercise cortisol attenuation in the VC group, 21.7+/-15.1 nmol/L (mean+/-SD) at baseline, to 13.5+/-10.0 at acute, to 7.6+/-4.2 after short term (P=.032). No differences were detected in ratio of s-IgA to protein or URTI symptoms between groups.

CONCLUSIONS: These data suggest that vitamin C supplementation can decrease postexercise cortisol in individuals performing exercise similar to that of a half-marathon or marathon in hot conditions. However, no changes in s-IgA and URTI were evident, possibly due to previous moderate training and reduced physical and psychological stress compared with athletes participating in ultramarathons.

PMID: 19223675 [PubMed - indexed for MEDLINE]

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J Sports Med Phys Fitness. 2008 Jun;48(2):217-24.
Effect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30-min exercise at 75% VO2max.

Nakhostin-Roohi B, Babaei P, RaHydromaxani-Nia F, Bohlooli S.

Department of Exercise Physiology, Guilan University, Rasht, Iran bnakhostin_aau@yahoo.com.
Abstract

AIM: Hypothetically, supplementation with the antioxidant vitamins C could alleviate exercise-induced lipid peroxidation. The purpose of this study was to evaluate the effect of vitamin C supplementation on exercise-induced lipid peroxidation, muscle damage and inflammation.

METHODS: Sixteen healthy untrained male volunteers participated in a 30-min exercise at 75% Vo2max. Subjects were randomly assigned to one of two groups: 1) placebo and 2) vitamin C (VC: 1 000 mg vitamin C). Blood samples were obtained prior to supplementation (baseline), 2 h after supplementation (immediately pre-exercise), post-exercise, 2 and 24 h after exercise. Plasma levels of VC, total antioxidant capacity (TAC), creatine kinase (CK), malondealdehyde (MDA), total leukocytes, neutrophils, lymphocytes, interleukin-6 (IL-6) and cortisol were measured.

RESULTS: Plasma vitamin C concentrations increased significantly in the VC in response to supplementation and exercise (P<0.05). TAC decreased significantly in Placebo group 24 h after exercise compared to pre-exercise (P<0.05). Although MDA levels were similar between groups at baseline, it increased significantly 2 h after exercise only in the Placebo group (P<0.05). CK increased immediately and 2 h after exercise in both groups and 24 h after exercise only in placebo group compared to pre-exercise (P<0.05). Markers of inflammation (total leukocyte counts, neutrophil counts and IL-6) were increased significantly in response to the exercise (P<0.05). In VC group, there was significant increase in lymphocyte counts immediately after exercise compared with pre-exercise (P<0.05). Serum cortisol concentrations significantly declined after supplementation compared with baseline (P<0.05) as well as declined 2 and 24 h after exercise compared with immediately after exercise in VC group (P<0.05).

CONCLUSION: VC supplementation prevented endurance exercise-induced lipid peroxidation and muscle damage but had no effect on inflammatory markers.

PMID: 18427418 [PubMed - indexed for MEDLINE]

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Am J Clin Nutr. 2007 Jul;86(1):145-9.
Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone.

Padayatty SJ, Doppman JL, Chang R, Wang Y, Gill J, Papanicolaou DA, Levine M.

Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, National Institute of Child Health and Human Development, Bethesda, MD 20892-1372, USA.

Comment in:

* Am J Clin Nutr. 2008 Jan;87(1):191; author reply 191-2.

Abstract

BACKGROUND: When vitamin C intake is from foods, fasting plasma concentrations do not exceed 80 micromol/L. We postulated that such tight control permits a paracrine function of vitamin C.

OBJECTIVE: The purpose of this study was to determine whether paracrine secretion of vitamin C from the adrenal glands occurs.

DESIGN: During diagnostic evaluation of 26 patients with hyperaldosteronism, we administered adrenocorticotrophic hormone intravenously and measured vitamin C and cortisol in adrenal and peripheral veins.

RESULTS: Adrenal vein vitamin C concentrations increased in all cases and reached a peak of 176 +/- 71 micromol/L at 1-4 min, whereas the corresponding peripheral vein vitamin C concentrations were 35 +/- 15 micromol/L (P<0.0001). Mean adrenal vein vitamin C increased from 39 +/- 15 micromol/L at 0 min, rose to 162 +/- 101 micromol/L at 2 min, and returned to 55 +/- 16 micromol/L at 15 min. Adrenal vein vitamin C release preceded the release of adrenal vein cortisol, which increased from 1923 +/- 2806 nmol/L at 0 min to 27 191 +/- 16 161 nmol/L at 15 min (P<0.0001). Peripheral plasma cortisol increased from 250 +/- 119 nmol/L at 0 min to 506 +/- 189 nmol/L at 15 min (P<0.0001).

CONCLUSIONS: Adrenocorticotrophic hormone stimulation increases adrenal vein but not peripheral vein vitamin C concentrations. These data are the first in humans showing that hormone-regulated vitamin secretion occurs and that adrenal vitamin C paracrine secretion is part of the stress response. Tight control of peripheral vitamin C concentration is permissive of higher local concentrations that may have paracrine functions.

PMID: 17616774 [PubMed - indexed for MEDLINE]

Thanks