Hi_I_AM_neW19

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Hello guys i am thinking about increasing elastin in my body if it's good for gains.The penis it's ligament muscle,skin that it's elastic so it's elastic because of the elastin in it...i know that 52% elastin,48 collagen it's good for the penis,but do increased elastin make bigger penis?or bigger chance to make it bigger?if so how can we increase the elastin in bodies?
 
Ingesting collagen has been stated to improve nutrition when combined with vegetables and one spokeswoman even claims that "Collagen is a kind of protein that forms bones, skin and many other tissues. It especially forms large parts of inner skin. Studies imply that eating or drinking collagen improves bone metabolism and is good for people suffering joint inflammation and osteoporosis." In addition, it has been reported in a preliminary experiment that eating or drinking collagen helps the skin stay moist.

The woman did not go so far as to say ingesting collagen is more effective than other types of protein. (Collagen is digested into amino acids just like fish, chicken, eggs, etc...).

Collagen accounts for a third of protein forming animal bodies, so it is correct to say it is a very necessary protein. Also, it accounts for 70 percent of the weight of inner skin when it is completely dehydrated, apparently.

However, I haven't actually read any of the studies done and this is all just apparent from some articles published in Japan Times.

~~~~~~~~

There is however one supplements that I take, which I believe is key to helping the body repair for Penis Enlargement. It's a combination of Glucosamine, Chondroitin, and MSM.

Glucosamine is a compound found naturally in the body, made from glucose and the amino acid glutamine. Glucosamine is needed to produce glycosaminoglycan, a molecule used in the formation and repair of cartilage and other body tissues. Production of glucosamine slows with age, so therefore nutritional supplementation can benefit individuals who suffer from osteoarthritis and other conditions such as rheumatoid arthritis, inflammatory bowel disease (Crohn's disease and ulcerative colitis), chronic venous insufficiency, and skin conditions.

Glucosamine is often combined with chondroitin sulfate, a molecule naturally present in cartilage. Chondroitin gives cartilage elasticity and is believed to prevent the destruction of cartilage by enzymes. Glucosamine is sometimes combined with MSM (methylsulfonylmethane), in nutritional supplements.

Here are a couple studies.

~~~~~~~~

Int J Mol Med. 2011 Apr 29. doi: 10.3892/ijmm.2011.686. [Epub ahead of print]


Effect of glucosamine, a therapeutic agent for osteoarthritis, on osteoblastic cell differentiation.

Igarashi M, Sakamoto K, Nagaoka I.

Department of Host Defense and Biochemical Research, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8421, Japan.


Abstract

Osteoarthritis (OA) is characterized by qualitative and quantitative changes in the architecture and composition of all the joint structures. Glucosamine (GlcN) has been used to treat OA in humans, because GlcN is present in the cartilage tissues as a component of glycosaminoglycans, and exhibits the symptom-modifying effect on OA by normalizing cartilage metabolism. On the other hand, the pathological change of subchondral bone is associated with the initiation and progression of cartilage damage in OA. However, the effect of GlcN on bone metabolism remains unsolved. In the present study, we determined the effect of GlcN on bone metabolism (osteoblastic cell differentiation) using mouse osteoblastic MC3T3-E1 cells by evaluating the expression of early (type I collagen and alkaline phosphatase), middle (osteopontin) and late (osteocalcin and mineralization) stage differentiation markers, and further compared its effects to those of N-acetyl-D-glucosamine (GlcNAc), a derivative of GlcN. The results indicated that the mineralization of mature osteoblasts was increased by treatment with GlcN and GlcNAc. Furthermore, reverse transcription-polymerase chain reaction (RT-PCR) analyses revealed that GlcN and GlcNAc substantially increased the expression of a middle stage marker and a late stage marker, although they did not essentially affect the expression of early stage markers. In addition, GlcN and GlcNAc suppressed the expression of receptor activator of NF-κB ligand (RANKL), a key factor involved in the osteoclastic cell differentiation and activation. Together these observations suggest that both GlcN and GlcNAc may have a potential not only to induce osteoblastic cell differentiation especially at middle-late stages, but also to suppress the osteoclastic cell differentiation, thereby possibly increasing bone matrix deposition and decreasing bone resorption, and eventually modulating bone metabolism in OA.

PMID: 21537831 [PubMed - as supplied by publisher]

~~~~~~~~

Eur Cell Mater. 2011 Mar 15;21:259-71; discussion 270-1.


A preliminary study of the effects of glucosamine sulphate and chondroitin sulphate on surgically treated and untreated focal cartilage damage.

Kamarul T, Ab-Rahim S, Tumin M, Selvaratnam L, AHydromaxad TS.

Department of Orthopaedic Surgery (NOCERAL), University of Malaya, Kuala Lumpur, Malaysia.


Abstract

The effects of Glucosamine Sulphate (GS) and Chondroitin Sulphate (CS) on the healing of damaged and repaired articular cartilage were investigated. This study was conducted using 18 New Zealand white rabbits as experimental models. Focal cartilage defects, surgically created in the medial femoral condyle, were either treated by means of autologous chondrocyte implantation (ACI) or left untreated as controls. Rabbits were then divided into groups which received either GS+/-CS or no pharmacotherapy. Three rabbits from each group were sacrificed at 12 and 24 weeks post-surgery. Knees dissected from rabbits were then evaluated using gross quantification of repair tissue, glycosaminoglycan (GAG) assays, immunoassays and histological assessments. It was observed that, in contrast to untreated sites, surfaces of the ACI-repaired sites appeared smooth and continuous with the surrounding native cartilage. Histological examination demonstrated a typical hyaline cartilage structure; with proteoglycans, type II collagen and GAGs being highly expressed in repair areas. The improved regeneration of these repair sites was also noted to be significant over time (6 months vs. 3 months) and in GS and GS+CS groups compared to the untreated (without pharmacotherapy) group. Combination of ACI and pharmacotherapy (with glucosamine sulphate alone/ or with chondroitin sulphate) may prove beneficial for healing of damaged cartilage, particularly in relation to focal cartilage defects.

PMID: 21409755 [PubMed - in process]

~~~~~~~~

I take a supplement 2 times/day, once in the AM and once before bed, by NOW foods called Glucosamine & Chondroitin with MSM. I think it has helped me recover from heavy stretching. Every morning when I wake up, I feel fresh and ready to stretch. I almost never take days off, and I believe it really helps.

To completely change topics, I have heard that IGF-1 may exhibited better cartilaginous features than chondroitin. Here's another study.

~~~~~~~~

J Cell Physiol. 2011 Aug;226(8):1981-8. doi: 10.1002/jcp.22530.

Differential effect of ECM molecules on re-expression of cartilaginous markers in near quiescent human chondrocytes.

Chiu LH, Chen SC, Wu KC, Yang CB, Fang CL, Lai WF, Tsai YH.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Cell and Molecular Biology, College of Medicine, Taipei Medical University, Taipei, Taiwan.


Abstract

The limited source of healthy primary chondrocytes restricts the clinical application of tissue engineering for cartilage repair. Therefore, method to maintain or restore the chondrocyte phenotype during in vitro expansion is essential. The objective of this study is to establish the beneficial effect of ECM molecules on restoring the re-expression of cartilaginous markers in primary human chondrocytes after extensive monolayer expansion. During the course of chondrocyte serial expansion, COL2A1, SOX9, and AGN mRNA expression levels, and GAG accumulation level were reduced significantly in serially passaged cells. Exogenous type II collagen dose-dependently elevated GAG level and induced the re-expression of cartilaginous marker mRNAs in P7 chondrocytes. Chondroitin sulfate did not show significant effect on P7 chondrocytes, while hyaluronic acid inhibited the expression of SOX9 and AGN mRNAs. Upon treatment with type II collagen, FAK, ERK1/2, and JNK were activated via phosphorylation in P7 chondrocytes within 15 min. Furthermore, GFOGER integrin blocking peptide, MEK inhibitor and JNK inhibitor, not p38 inhibitor, significantly reduced the type II collagen-induced GAG deposition level. Finally, in the presence of TGF-β1 and IGF-I, P7 chondrocytes cultured in 3D type II collagen matrix exhibited better cartilaginous features than those cells cultured in the type I collagen matrix. In conclusion, type II collagen alone can effectively restore cartilaginous features of expanded P7 human chondrocytes. It is probably mediated via the activation of FAK-ERK1/2 and FAK-JNK signaling pathways. The potential application of type II collagen in expanding a scarcity of healthy chondrocytes in vitro for further tissue engineering is implicated. J. Cell. Physiol. 226: 1981-1988, 2011. © 2010 Wiley-Liss, Inc.

Copyright © 2010 Wiley-Liss, Inc.

PMID: 21520049 [PubMed - in process]


~~~~~~~~

I haven't tried IGF-1 yet, and I believe Supra has a log or has done some experimentation with that. I'd be a willing lab-rat in the near future though! For now, I'll stick with my current nutritional supplementation of aminos and the a fore mentioned NOW foods product.
 
sizerp;430844 said:
Ingesting collagen has been stated to improve nutrition when combined with vegetables and one spokeswoman even claims that "Collagen is a kind of protein that forms bones, skin and many other tissues. It especially forms large parts of inner skin. Studies imply that eating or drinking collagen improves bone metabolism and is good for people suffering joint inflammation and osteoporosis." In addition, it has been reported in a preliminary experiment that eating or drinking collagen helps the skin stay moist.

The woman did not go so far as to say ingesting collagen is more effective than other types of protein. (Collagen is digested into amino acids just like fish, chicken, eggs, etc...).

Collagen accounts for a third of protein forming animal bodies, so it is correct to say it is a very necessary protein. Also, it accounts for 70 percent of the weight of inner skin when it is completely dehydrated, apparently.

However, I haven't actually read any of the studies done and this is all just apparent from some articles published in Japan Times.

~~~~~~~~

There is however one supplements that I take, which I believe is key to helping the body repair for Penis Enlargement. It's a combination of Glucosamine, Chondroitin, and MSM.

Glucosamine is a compound found naturally in the body, made from glucose and the amino acid glutamine. Glucosamine is needed to produce glycosaminoglycan, a molecule used in the formation and repair of cartilage and other body tissues. Production of glucosamine slows with age, so therefore nutritional supplementation can benefit individuals who suffer from osteoarthritis and other conditions such as rheumatoid arthritis, inflammatory bowel disease (Crohn's disease and ulcerative colitis), chronic venous insufficiency, and skin conditions.

Glucosamine is often combined with chondroitin sulfate, a molecule naturally present in cartilage. Chondroitin gives cartilage elasticity and is believed to prevent the destruction of cartilage by enzymes. Glucosamine is sometimes combined with MSM (methylsulfonylmethane), in nutritional supplements.

Here are a couple studies.

~~~~~~~~

Int J Mol Med. 2011 Apr 29. doi: 10.3892/ijmm.2011.686. [Epub ahead of print]


Effect of glucosamine, a therapeutic agent for osteoarthritis, on osteoblastic cell differentiation.

Igarashi M, Sakamoto K, Nagaoka I.

Department of Host Defense and Biochemical Research, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8421, Japan.


Abstract

Osteoarthritis (OA) is characterized by qualitative and quantitative changes in the architecture and composition of all the joint structures. Glucosamine (GlcN) has been used to treat OA in humans, because GlcN is present in the cartilage tissues as a component of glycosaminoglycans, and exhibits the symptom-modifying effect on OA by normalizing cartilage metabolism. On the other hand, the pathological change of subchondral bone is associated with the initiation and progression of cartilage damage in OA. However, the effect of GlcN on bone metabolism remains unsolved. In the present study, we determined the effect of GlcN on bone metabolism (osteoblastic cell differentiation) using mouse osteoblastic MC3T3-E1 cells by evaluating the expression of early (type I collagen and alkaline phosphatase), middle (osteopontin) and late (osteocalcin and mineralization) stage differentiation markers, and further compared its effects to those of N-acetyl-D-glucosamine (GlcNAc), a derivative of GlcN. The results indicated that the mineralization of mature osteoblasts was increased by treatment with GlcN and GlcNAc. Furthermore, reverse transcription-polymerase chain reaction (RT-PCR) analyses revealed that GlcN and GlcNAc substantially increased the expression of a middle stage marker and a late stage marker, although they did not essentially affect the expression of early stage markers. In addition, GlcN and GlcNAc suppressed the expression of receptor activator of NF-κB ligand (RANKL), a key factor involved in the osteoclastic cell differentiation and activation. Together these observations suggest that both GlcN and GlcNAc may have a potential not only to induce osteoblastic cell differentiation especially at middle-late stages, but also to suppress the osteoclastic cell differentiation, thereby possibly increasing bone matrix deposition and decreasing bone resorption, and eventually modulating bone metabolism in OA.

PMID: 21537831 [PubMed - as supplied by publisher]

~~~~~~~~

Eur Cell Mater. 2011 Mar 15;21:259-71; discussion 270-1.


A preliminary study of the effects of glucosamine sulphate and chondroitin sulphate on surgically treated and untreated focal cartilage damage.

Kamarul T, Ab-Rahim S, Tumin M, Selvaratnam L, AHydromaxad TS.

Department of Orthopaedic Surgery (NOCERAL), University of Malaya, Kuala Lumpur, Malaysia.


Abstract

The effects of Glucosamine Sulphate (GS) and Chondroitin Sulphate (CS) on the healing of damaged and repaired articular cartilage were investigated. This study was conducted using 18 New Zealand white rabbits as experimental models. Focal cartilage defects, surgically created in the medial femoral condyle, were either treated by means of autologous chondrocyte implantation (ACI) or left untreated as controls. Rabbits were then divided into groups which received either GS+/-CS or no pharmacotherapy. Three rabbits from each group were sacrificed at 12 and 24 weeks post-surgery. Knees dissected from rabbits were then evaluated using gross quantification of repair tissue, glycosaminoglycan (GAG) assays, immunoassays and histological assessments. It was observed that, in contrast to untreated sites, surfaces of the ACI-repaired sites appeared smooth and continuous with the surrounding native cartilage. Histological examination demonstrated a typical hyaline cartilage structure; with proteoglycans, type II collagen and GAGs being highly expressed in repair areas. The improved regeneration of these repair sites was also noted to be significant over time (6 months vs. 3 months) and in GS and GS+CS groups compared to the untreated (without pharmacotherapy) group. Combination of ACI and pharmacotherapy (with glucosamine sulphate alone/ or with chondroitin sulphate) may prove beneficial for healing of damaged cartilage, particularly in relation to focal cartilage defects.

PMID: 21409755 [PubMed - in process]

~~~~~~~~

I take a supplement 2 times/day, once in the AM and once before bed, by NOW foods called Glucosamine & Chondroitin with MSM. I think it has helped me recover from heavy stretching. Every morning when I wake up, I feel fresh and ready to stretch. I almost never take days off, and I believe it really helps.

To completely change topics, I have heard that IGF-1 may exhibited better cartilaginous features than chondroitin. Here's another study.

~~~~~~~~

J Cell Physiol. 2011 Aug;226(8):1981-8. doi: 10.1002/jcp.22530.

Differential effect of ECM molecules on re-expression of cartilaginous markers in near quiescent human chondrocytes.

Chiu LH, Chen SC, Wu KC, Yang CB, Fang CL, Lai WF, Tsai YH.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Cell and Molecular Biology, College of Medicine, Taipei Medical University, Taipei, Taiwan.


Abstract

The limited source of healthy primary chondrocytes restricts the clinical application of tissue engineering for cartilage repair. Therefore, method to maintain or restore the chondrocyte phenotype during in vitro expansion is essential. The objective of this study is to establish the beneficial effect of ECM molecules on restoring the re-expression of cartilaginous markers in primary human chondrocytes after extensive monolayer expansion. During the course of chondrocyte serial expansion, COL2A1, SOX9, and AGN mRNA expression levels, and GAG accumulation level were reduced significantly in serially passaged cells. Exogenous type II collagen dose-dependently elevated GAG level and induced the re-expression of cartilaginous marker mRNAs in P7 chondrocytes. Chondroitin sulfate did not show significant effect on P7 chondrocytes, while hyaluronic acid inhibited the expression of SOX9 and AGN mRNAs. Upon treatment with type II collagen, FAK, ERK1/2, and JNK were activated via phosphorylation in P7 chondrocytes within 15 min. Furthermore, GFOGER integrin blocking peptide, MEK inhibitor and JNK inhibitor, not p38 inhibitor, significantly reduced the type II collagen-induced GAG deposition level. Finally, in the presence of TGF-β1 and IGF-I, P7 chondrocytes cultured in 3D type II collagen matrix exhibited better cartilaginous features than those cells cultured in the type I collagen matrix. In conclusion, type II collagen alone can effectively restore cartilaginous features of expanded P7 human chondrocytes. It is probably mediated via the activation of FAK-ERK1/2 and FAK-JNK signaling pathways. The potential application of type II collagen in expanding a scarcity of healthy chondrocytes in vitro for further tissue engineering is implicated. J. Cell. Physiol. 226: 1981-1988, 2011. © 2010 Wiley-Liss, Inc.

Copyright © 2010 Wiley-Liss, Inc.

PMID: 21520049 [PubMed - in process]


~~~~~~~~

I haven't tried IGF-1 yet, and I believe Supra has a log or has done some experimentation with that. I'd be a willing lab-rat in the near future though! For now, I'll stick with my current nutritional supplementation of aminos and the a fore mentioned NOW foods product.

so nice,so so nice!wonderful,but don't you think that when collagen increase the elastin drop down,and when elastin increase,collagen drop down?how to increase our elastin in our penis?
 
Hi_I_AM_neW19;430943 said:
so nice,so so nice!wonderful,but don't you think that when collagen increase the elastin drop down,and when elastin increase,collagen drop down?how to increase our elastin in our penis?

No, I think you are a bit confused on the actual, basic functions of collagen and elastin.

Read this:

Collagen and elastin are structural proteins made and used in the human body. Collagen is found primarily in tendons, ligaments, and the connective tissue of skin, blood vessels, and lungs. Elastin is found primarily in the artery walls, lungs, intestines, and skin. These proteins work in partnership in connective tissues.

Function


Collagen gives connective tissue and organs rigidity so that they can function, and elastin lets them stretch and return to their original state. Collagen does not allow the elastin to stretch to the point of breaking. In the skin, collagen and elastin are the primary components of the dermis--the layer right beneath the epidermis. They provide the support structure of the skin.

Significance


The human body stops producing elastin when you hit puberty. This is when the aging process begins. Without elastin replenisHydromaxent, collagen begins to lose its elasticity and begins to weaken. The loss of the skin's tone and resiliency are the most common visual markers of this process. Facial expressions begin to put stress on collagen and after a period of time, wrinkles begin to appear.

Misconceptions


Some companies advertise the use of collagen and elastin in their anti-aging creams and moisturizers; however, these products work only on the skin surface. According to the contributing dermatologists at MedicineNet, creams and moisturizers cannot penetrate the skin and are not designed to be absorbed; therefore they will not undo the cumulative effect of collagen loss. The creams slow the rate of water loss and keep the skin supple.

http://www.ehow.com/about_5315452_collagen-elastin.html


There isn't much research that I could find relating collagen to male sex organs, however, it is quite interesting. To be honest, I am sure if you did some more thorough searching you may uncover some kind of correlation between the penis and collagen and elastin levels/density.

Good luck! If you read anything more please share.
 
Good work sizerp.
Hey 19, you might want to look up Vitamin C and copper and their effects on collagen and elastin. Might answer some questions for ya that you might not have thought about.
 
MAXAMEYES;431204 said:

Really? Never knew that. I have fairly young looking skin as I do not sun and wear dark glasses all the time but I think I may take your advice for preventive maintenance. I want to look young forever!
 
And Vitamin C is absolutely essential for copper absorption and collagen formation; that's just one reason I'm The Pusher Man for "C".

doublelongdaddy;431236 said:
Really? Never knew that. I have fairly young looking skin as I do not sun and wear dark glasses all the time but I think I may take your advice for preventive maintenance. I want to look young forever!
 
Hi_I_AM_neW19;431399 said:
Vitamin C and copper or zinc!
anyone else with more supplement for collagen and elastin?

You could take ZMA (Zinc monomethionine aspartate and Magnesium Aspartate + a tad of Vitamin B6). May increase your loads with that one too. I take it before bed on an empty stomach (about 1.5-2 hours after my last meal).
 
sizerp;431430 said:
You could take ZMA (Zinc monomethionine aspartate and Magnesium Aspartate + a tad of Vitamin B6). May increase your loads with that one too. I take it before bed on an empty stomach (about 1.5-2 hours after my last meal).

this is one of the best supplements for increasing testesterone,but what this supplement have with elastin?
 
Hi_I_AM_neW19;431609 said:
this is one of the best supplements for increasing testesterone,but what this supplement have with elastin?

Recovery.
 
sizerp;430844 said:
~~~~~~~~

There is however one supplements that I take, which I believe is key to helping the body repair for Penis Enlargement. It's a combination of Glucosamine, Chondroitin, and MSM.

Glucosamine is a compound found naturally in the body, made from glucose and the amino acid glutamine. Glucosamine is needed to produce glycosaminoglycan, a molecule used in the formation and repair of cartilage and other body tissues. Production of glucosamine slows with age, so therefore nutritional supplementation can benefit individuals who suffer from osteoarthritis and other conditions such as rheumatoid arthritis, inflammatory bowel disease (Crohn's disease and ulcerative colitis), chronic venous insufficiency, and skin conditions.

Glucosamine is often combined with chondroitin sulfate, a molecule naturally present in cartilage. Chondroitin gives cartilage elasticity and is believed to prevent the destruction of cartilage by enzymes. Glucosamine is sometimes combined with MSM (methylsulfonylmethane), in nutritional supplements.
 
Ditto on this sizerp. A Glucosamine-Chondroitin-MSM combo is an excellent supplement for recovery and is currently being used alot by MMA for repair/recovery of joints, ligaments, and cartilage. I recently started a regiment of this. With all of the hanging and bundled twisting I have been doing, it allows me to go at it hard the next day. It is now a permanent addition to my Penis Enlargement Toolbox!
 
If we need magnesium, zinc, selenium, we can supplement.

If we have low bio-available copper, just supplementing copper will not help and might drop the copper where it will harm. Copper is in the middle, a sort of catalyst. If we have low bio-available copper, the body will sacrifice sex hormones i.e. *-sterones for their copper!

If I remember, people who crave blueberries for their copper, may have high iron, low copper-zinc-selenium.

We might be able to word search on bio-available copper and find something useful. Turmeric, curcumin, and blood donation help to reduce or regulate iron. Bombing with good mineral supplement which includes molybdenum, and trace minerals, over a three month period, ought to put us in line, add turmeric extract or curcumin, maybe donate blood.
 
Vitamin C and vitamin E are best. Also spending too much time in the sun can breakdown the collagen and elastin in your skin. Smoking can also prematurely break down collagen, resulting in wrinkles.
 
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