8 X 8

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greetings.
if anyone knows the size of the tadalafil(liquid cialis) molecule, and whether or not a topical application inside the urethra, using no carrier, is:
1. possible
2. effective
3. if localized absorption is strong, how much to reduce dose by?
4. any side effects of this application?

if topical application of liquid cialis is not possible or has too many side effects this way:
1. can it be topically applied, with or w/o carrier, to the glans or shaft skin?
2. if a carrier is required for this method, which carrier is best?

thank you for any answers, questions, or comments.:cool:
 
I know the oral method is widely used, and used safely, but I ask this for several reasons:
1. To keep the effects as localized as possible.
in addition to being a PDE5 blocker, tadalafil is a quasi-PDE11 blocker, and while there are no known side effects for this, PDE11 is involved in the kidneys, skeletal muscle, and other organs. And even though the PDE11 blocking is 14 times less than tadalafil's PDE5 blocking, it still has some small effect, and it is not known if this small effect can cause a tiny imbalance.

i'd rather keep my research as localized as possible.

Other unintended benefits might possibly be:
2. Faster action by the tadalafil on the glans and corpus (5 minutes instead of 45min)
3. Lower mg dose needed to achieve what 10-15mg can achieve thru an oral dose ($ savings)

That said, if their are serious drawbacks or irritation/contraindications to this method of urethral application, what carrier is needed to apply liquid cialis transdermally thru the glans or shaft skin? Again, thanks for any answers, discusiion, questions, or comments.
 
This is somthing i would also like to know!
I would like to try some tadalafil powder dissolved in dmso.
dont yet know if i can get the powder.
the pills have binders in them that would need to be removed.

I have suffered through very bad systemic side effects from small dose of tadalafil.
 
Well, I am considering ordering the powdered Tadalafil for researching this urethral/topical application style. After having found ChemOne's Liquid tadalafil to have good quality, will I be satisfied with the Powdered tadalafil from Elitenet pharm? Or does someone have a better source for the purest powdered tadalafil ?
 
Wow, this is turning into chemistry class 101!:)
 
8 X 8;348866 said:
greetings.
if anyone knows the size of the tadalafil(liquid cialis) molecule
Apparently the molecular weight of Tadalafil is 389.41, small enough for DMSO to take it in transdermally, and DMSo's efficiency is very high, taking 80-90% of the tadalafil in, a much higher percentage than if tadalafil is ingested orally, I think. And DMSO's penetration time is very short, just a few seconds for it to penetrate and deliver.

But I am trying to avoid regular use of DMSO, as there are some studies which have linked it, in infants, to neuro-degenerative problems. I realize that as a grown man, at the small dose of DMSo this wtransdermal application would require, any neurological side effect would be minimal, but I still avoid alcohol/ethanol/etc. in almost every form (except cologne), and I hope to avoid DMSO likewise.

Does anyone know other, milder transdermal carriers, capable of taking in solutes with a molecular weight of 389.41, with perhaps less efficiency, and a slower penetration time?
 
I have found something which is interesting regarding urethral/transdermal tadalafil application:

When I took Tadalafil orally, I noticed I got mild heartburn. Apparenty this is a symptom that occurs in some users, and I looked into why this is, and found some user-claims that Tadalafil caused esophageal erosion, so that immediately caused me to assume that it has a corrosive effect on mucous membranes, making the urethral application a big no-no, as I've already had a UTI, and don't want the burning urine again.

But after further research, the user's assumption was incorrect, the reason Tadalafil causes heartburn is not due to it having a corrosive force on the esophogus at all, it is due to it relaxing the lower esophogeal sphincter, which is the thing that opens when food enters the stomach, then closes as to not allow any food or stomach acid to come back up.

So, taking a urethral dose, will likely make the effects less systemic, and tending to be more localized, which would likely significantly lessen the heartburn inducing esophogeal-sphincter-relaxation.
 
The Organic Chemistry Researcher in me is Screaming for you to not to apply the DMSO solution to your urethra.

DMSO is one of the strongest solvent used readily in organic chemistry. In general, it is only used after all the hexane & 6-membered ring Halogenated solvents are used. Due to the fact that DMSO is a small charged species of molecule, it assimilates readily around various compounds "cushioning" the various charged parts on the molecule you are looking to dissolve. This "cushioning" is what causes the dissolving phenomenon. DMSO is a very powerful dissolving agent whose inherent charge causes those things dissolved in it to stay "stuck magnetically" to it. The small size of the DMSO molecule and it's charge is also what gives it such a penetration effect.

When first learning of DMSO, my Organic Chemistry Professor made us all stop and put down our pens. She then went on to tell us how much she cared about us individually, and explained that she understood that since a good 40% of the class where student athletes we may be implored to use DMSO to rub into our bodies as it is considered an effective pain treatment and salve. She asked us all to promise never to use it in such a way, simply because you can never be too cautious of having removed everything harmful from the skin. Of course you can kill all germs/bacteria on the skin, but we are talking about things on a chemical level once you introduce DMSO to the situation and in her words, "If it's on your skin, it's gonna travel into your blood stream and into your muscle (etc.) possibly permanently."

As far as a carrier molecule goes, see if it dissolves in Ethanol. All the other solvents I can think of are essentially too toxic to recommend, including Methanol.

My thinking is, if it dissolves in ethanol then you should be able to absorb it without a problem because ethanol absorbs through the skin very easily..... However, you will still have the main issue of avoiding a chemical burn, the same way you would with DMSO.

In closing, bro, please don't put the DMSO into your urethra. Tip toe with its use topically on your penile skin b/c it is very different [much more delicate] than the other areas of skin people have use DMSO on.

Keep a journal and remember that you can tell the stuff working by the presence of an erection, so there is no need to do too much too soon.

In general, things that go into the urethra are benign and none reactive or polarized. Dimethyl-sulfoxide does not fit in that category. If hell bent on urethral use, dissolve in a small amount of DMSO and mix with some thing benign before introducing to urethra.
 
Here i am several years later. having only applied Tadalafil to my urethra without DMSO. i'm considering doing very small doses with dmso shortly, as airsealed2 has the powder back in stock. Wish me luck :)
 
8 X 8;505969 said:
Here i am several years later. having only applied Tadalafil to my urethra without DMSO.


Anything notable? Gains perhaps?
 
I've started doing the urethral transdermal experiments with tadalafil and sildanafil dissolved in 99.9% pure DMSO. Will report back shortly as to if the effects are more localized or still systemic.
 
OMG I feel like I'm going to get priapism !!! WOW!
It definitely works, now let's see if it stays more localized or still goes systemic !!!
 
8 X 8;517170 said:
OMG I feel like I'm going to get priapism !!! WOW!
It definitely works, now let's see if it stays more localized or still goes systemic !!!

Can you explain exactly how you do this and what I would need to try it out?
 
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