SNKRhead5O;507511 said:
I have scar tissue in my penis from peyronies no curve my doctor prescribed colcrys 0.6 mg's twice a day with naproxen 375 mg's twice a day as needed for pain I was wondering of anyone knows anything about these medications & their affects the colcrys says its to prevent gout how would tht help peyronies ? & would taking these pills affect my gains ? I've had peyronies about a year now should I take these pills or not ?
This may help:
"The best way to understand the controversy is to follow Gelbard's work, in my opinion. Also, remember there are several collagenase enymes in the body - and it is not entirely clear what Gelbard was studying vs. what Auxilium is running in trials - though they are obviously very similar.
"Collagenase causes extensive dissolution in vitro of the tissue comprising Peyronie's plaques, as well as normal tunica albuginea. There are factors which may ovvercome thi slack of selectivity and permit its clinical us e in the treatment o f Peyronies Disease." - Gelbard, 1982
Gelbard subsequently patented the use of purified clostridial collagenase for Peyronies Disease in 1982. His patent is very complex, but it appears he might find some selectivity by the collagenase enzyme (for the plaque vs. the tunica) under certain circumstances. Here is how he describes treated plauque:
"Treated plaque showed widespread fraying and dispersal of collagen bundles compared to the dense compact collagen seen in untreated tissue....very little diffusion and spreading occur from the site of initial enzyme deposition....elastic tissue is preserved, which may be particularly important in treating Peyronies Disease..."
In 1985, Gelbard has some success, but has a setback with a patient with a corporeal rupture
http://www.ncbi.nlm.nih.gov/puBathmateed/2991611
Gelbard, 1993 reverses his opinion on the negative effects of collagenase from his clinical trial:
http://www.ncbi.nlm.nih.gov/puBathmateed/8417217
I don't know if Gelbard was using what Auxilium is using...two other patents have been filed since his patent.
In vitro, I think AUX collagenase was shown to dissolve the plaque of peyronie's in greater quantities than the tunica albuginea. Why this would be is unknown and makes no theoretical sense. I don't have the reference to the paper (or i might just not be remembering it right). I know there is research where they took peyronie's plaques from surgical patients, cut them up, and then exposed them to xiaflex. I THINK Xiaflex reacted more with the plaque - possibly because it had more collagen or that enzyme had a greater affinity for disorganized collagen which comprises the plaque. It did not affect elastin. In vivo, 0.58 mg is a very small dose, so the dissolved collagen should just be broken into smaller pieces that can be dislodged and absorbed by the body. "
-MikeSmith0