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"HGH and IGF Chem PE"
#1
Going to to use HGH and IGF-1, I dont recommend anyone inject into there penis. Dont try this at home:)
 
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"HGH and IGF Chem PE"
#2
This is what my freind told me

"You can inject IGF-1 anywhere on the body sub-q ie. calves, abdominals, shoulder areas, arms,etc. as it will all enter systemic blood circulation shortly after administration.

The irritation/inflamation is also experienced by administration of HGH and is more prevelant in some users than others. It should go away soon, if you're experiencing any at all. Just make sure to rotate your injection sites.

Check with your urologist regarding safety about injecting in the cc and cs in the penis, if you want the maximum amount of proliferation/hyperplasia of cells(growth) in this area."
 

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"HGH and IGF Chem PE"
#3
: Biochem Biophys Res Commun. 2001 Feb 9;280(5):1307-15. Related Articles, Links


Insulin-like growth factor-I promotes proliferation and migration of cavernous smooth muscle cells.

Liu X, Lin CS, Spencer EM, Lue TF.

Knuppe Molecular Urology Laboratory, University of California, San Francisco, California 94143-1695, USA.

To better understand the physiology of cavernous smooth muscle cells (CSMC), particularly their regulation by IGF-I, we isolated CSMC from rats of various ages and grew them as cell cultures. CSMC from very young (1 week of age) and very old (28 months of age) rats secreted the least amounts of IGF-I, and those from 16-week-old rats the most. IGF-I stimulated growth of CSMC at an optimal concentration of 12.5 ng/ml. At this concentration, CSMC from 11-week-old rats showed the highest growth rate and CSMC from 28-month-old rats showed the lowest. The optimal IGF-I concentration for migration of CSMC was 10 ng/ml. At this concentration, CSMC from 4-week-old rats showed the highest migratory rate and CSMC from 28-month-old rats showed the lowest. IGF-I also stimulated VEGF secretion from CSMC at an optimal concentration of 10 ng/ml. At this concentration, CSMC from 16-week-old rats secreted VEGF the most and CSMC from 28-month-old rats secreted the least. The expression levels of IGF-IR paralleled the IGF-I-regulated growth rates of these cells. Expression of IGF-IR was identified in the cavernous smooth muscle and the urethra epithelium of the penis.
 

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#4
1: Eur J Endocrinol. 1998 Feb;138(2):176-80. Related Articles, Links


Effect of insulin-like growth factor-I treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance).

Laron Z, Klinger B.

Endocrine and Diabetes Research Unit, Schneider Children's Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel.

Serum gonadotrophins. androgens, insulin and insulin-like growth factor-I (IGF-I) were determined before and during long-term treatment with recombinant IGF-I of seven males with Laron syndrome, and the changes correlated with changes in testicular volume and penile size. The subjects were four boys below the age of 5, two boys aged 10 and 14 but prepubertal and one 28-year-old fully sexually developed adult. IGF-I was administered by a once daily subcutaneous injection of 150 microg/kg per day to the boys and 120 microg/kg per day to the adult patient. In the very young boys no change in serum gonadotrophins, androgens, gonads or genitals was registered. In the two older boys and the adult patient, there was a progressive rise in luteinizing hormone, follicle-stimulating hormone and testosterone. Concomitantly, there was an increase in size of the testes and penile length . The two boys started puberty. As very high serum IGF-I levels were registered in the adult patient, the daily dose was progressively decreased to 70 microg/kg per day. Stopping the IGF-I administration in this patient, according to the protocol, led to a return to pretreatment serum levels and testicular and penile size. This report shows for the first time a direct effect of IGF-I on sex hormones and sex organs in the male.
 

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"HGH and IGF Chem PE"
#5
Androl. 1993 Mar-Apr;14(2):73-8. Related Articles, Links


Insulin-like growth factor 1, but not growth hormone, has in vitro proliferative effects on neonatal foreskin fibroblasts without affecting 5-alpha-reductase or androgen receptor activity.

Dykstra KD, Payne AM, Abdelrahim M, Francis GL.

Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Clinical observation of patients with congenital growth hormone (GH) deficiency and Laron-type dwarfism suggests that factors such as GH or insulin-like growth factor 1 (IGF-1) might in addition to androgens, be needed for normal phallic growth. We speculated GH or IGF-1 might have direct actions on genital tissues and performed the present study to evaluate the in vitro effects of GH and IGF-1 on cultured neonatal foreskin fibroblasts. Cells derived from foreskins of normal newborns were studied between cell passages 6 and 15. Serum-free media with and without 100 ng/ml GH, IGF-1, or both were added 24 hours prior to and at the time of study. To determine the activity of 5-alpha-reductase (5-alpha-R), 3H-testosterone (T: 2 nM) was added, and 5-alpha-R activity was calculated as femtomoles 3H-dihydrotestosterone and 3H-androstanediol produced/microgram DNA/hour. Androgen receptor (AR) binding was determined by the addition of 3H-dihydrotestosterone (dHT; 0.03125-0.5 nM) in the presence and absence of a 200-fold excess of unlabeled dHT. Specific binding was used in Scatchard analysis for determination of AR number (Bmax) and binding affinity (Kd). The rate of DNA synthesis was determined by incorporation of 3H-thymidine (3H-Thy) into trichloroacetic acid-insoluble material. DNA and protein content were determined on cell lysates. IGF-1, but not GH, had proliferative effects (significant increases in the rate of 3H-Thy incorporation, DNA, and protein content) but no effect on 5-alpha-R activity, Bmax or Kd.(ABSTRACT TRUNCATED AT 250 WORDS)
 

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"HGH and IGF Chem PE"
#7
Just did my first shot of IGF-1 in the penis, I did 10mcg's on my penis and 30 in my stomach
 

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#8
I am debating whether ot not to just inject in my penis at 10mcg's a day for a while or stick with doing it in my calves as well at 30mcg's a day
 
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"HGH and IGF Chem PE"
#9
You found the study, nice! Did the penile injection hurt? Did you do it sub-q or like it was on the website?
 
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"HGH and IGF Chem PE"
#11
So, reading those studies it said that pretreatment size returned to the penis once IGF injections were halted. Also, how long does it take for a physical difference to take effect? Keep us posted!!!
 

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"HGH and IGF Chem PE"
#12
Yea I read that, but those people were not Doing Penis Enlargement like I am
 

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"HGH and IGF Chem PE"
#13
Well this seems to work well, my dick just got really full, I am going to keep doing it
 
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"HGH and IGF Chem PE"
#14
Fascinating stuff. So whatever changes you incur, according to the study, will be temporary.

Subscribing to this thread for sure.
 

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"HGH and IGF Chem PE"
#16
davidwh said:
Fascinating stuff. So whatever changes you incur, according to the study, will be temporary.

Subscribing to this thread for sure.

Mabey not, those people did not do Penis Enlargement, and IGF growth is permanant
 

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"HGH and IGF Chem PE"
#17
I am going to start shooting it right before or after I Penis Enlargement from now on
 
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"HGH and IGF Chem PE"
#20
Sounds promising, keep us posted
 

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