From Dr. Reicher: HGH and IGF-1 and penis enlargement

Note: This is NOT an instructional post on how to inject/ingest HGH
or IGF-1 for the purposes of enlarging your penis! This post is
merely an informational post that MAY show how such applications MAY
be used to treat penile "deficiencies" in the future (once more
research has been done to establish that there are no or minimal
side effects and that HGH/IGF-1 does actually enlarge the penis.)

There is a lot of excitement about Human Growth Hormone. It is
available by
injection only and is very expensive. It turns into IGF-1 after
injection
and the study below shows that it GROWS cells in the Penis EnlargementNIS. There
are plans
to release IFG-1 for injection ... could be a new method ...

Here is the ABSTRACT from 2001

Insulin-like growth factor-I promotes proliferation and migration of
cavernous smooth muscle cells.
Biochem Biophys Res Commun 2001 Feb 9;280(5):1307-15 (ISSN: 0006-
291X)
Liu X; Lin CS; Spencer EM; Lue TF
Knuppe Molecular Urology Laboratory, University of California, San
Francisco, California 94143-1695, USA.
To better understand the physiology of cavernous smooth muscle cells
(CSMC),
particularly their regulation by IGF-I, we isolated CSMC from rats
of
various ages and grew them as cell cultures. CSMC from very young (1
week of
age) and very old (28 months of age) rats secreted the least amounts
of
IGF-I, and those from 16-week-old rats the most. IGF-I stimulated
growth of
CSMC at an optimal concentration of 12.5 ng/ml. At this
concentration, CSMC
from 11-week-old rats showed the highest growth rate and CSMC from
28-month-old rats showed the lowest. The optimal IGF-I concentration
for
migration of CSMC was 10 ng/ml. At this concentration, CSMC from 4-
week-old
rats showed the highest migratory rate and CSMC from 28-month-old
rats
showed the lowest. IGF-I also stimulated VEGF secretion from CSMC at
an
optimal concentration of 10 ng/ml. At this concentration, CSMC from
16-week-old rats secreted VEGF the most and CSMC from 28-month-old
rats
secreted the least. The expression levels of IGF-IR paralleled the
IGF-I-regulated growth rates of these cells. Expression of IGF-IR
was
identified in the cavernous smooth muscle and the urethra epithelium
of the
penis.

Here is the LINK for the abstract:

http://www.kfinder.com/member-search/getdoc.cgi?
ord=12&searchid=8&have_local_holdings_file=0&local_journals_only=0

Take Care,

KMR

Good Health Begins at Home.

IGF-1 may give you cancer !

negative said:

IGF-1 may give you cancer !

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IGF-1 is produced naturally.

It is one of the hormones in the body that makes you grow.
If it gives you cancer, then why doesn't IGF-1 give bodybuilders cancer, who are people who will have elevated levels of IGF-1?

negative said:

IGF-1 may give you cancer !

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You obviously don't know what you're talking about... IGF does not give you cancer but it does cause hyperplasia so if you have cancer while taking it, IGF will provide an environment that will allow the cancer to flourish.

I can't get the link to work.

I have read a lot on IGF-1 and most of what I read said that 15mins of very intense exercise will raise natural IGF-1 levels for most of the day. Also I have read a few times that testosterone levels are elevated to maximum after only 30-45mins of intense exercise and that longer periods of exercise actually lower testosterone levels for up to 3 days. So I would say for maximum HGH,IGF-1, and testosterone release 30-45mins a day of running or weightlifting would be the best way to gain over all benefit of those hormones.

That may be true but the increased levels from intense exercize is nowhere near what exogenous application of IGF/test provides. The increases from exercise alone is a drop in the bucket compared to the levels that one can expect from injecting.

Yes, but the suppliment L-Arginine will also raise it. The question is how much would L-arginine along with weight or isometric exercise (to increase testosterone) raise HGH? Excess Aerobic exercise lowers testosterone levels. L-arginine is not expensive and does not have adverse effects on the body. When I first started taking it (along with other herbs and suppliments) I could actually feel new sensations at the end of the urethra at the tip of the penis. These suppliments alone have helped to give me gains.

sikdogg said:

You obviously don't know what you're talking about... IGF does not give you cancer but it does cause hyperplasia so if you have cancer while taking it, IGF will provide an environment that will allow the cancer to flourish.

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http://www.yourhealthbase.com/database/a109h.htm "They suggest that IGF-1 may increase both cell turnover and the susceptibility of cells to become cancerous"


http://www.yourhealthbase.com/database/a93h.htm "but high in IGF-1 levels had a 2.51 higher risk of colorectal cancer than did men with low IGF-1 levels"


http://www.ejnet.org/bgh/igf-1.html "The data revealed a significantly increased risk of prostate cancer in men with the highest levels of IGF-1"


Why take the chance ? You can make good gains without igf-1, with natural Penis Enlargement

I think its very strange Big Al post this article when saying on his page " How you can permanently add as much as 2 extra inches to your penis in just weeks." Why take hormons when you can gain 2 inch in weeks ? He he...


And this "Doctor" Dr. Reicher most be a great source *LOL*

Read below.





Androgel & Penis Enlargement (from Dr. Reicher)

Hey Al: Feel free to post my reply about my SUCCESS with Penis Enlargement and Androgel applied to the Penis EnlargementNIS. Remember www.tquiz.com will get you the RX you want from the doc! Good luck guyz, listen to BigAl, he is the CORE Guru. KR

>>>Big Al: Done Thanks!

>From: "Big Al"
>To: Dr. Reicher
>Subject: Re: ?Androgel + Penis Enlargement
>Date: Tue, 07 Aug 2001 01:29:54 -0700
>
>Hi,
>
>That's an interesting question. I've heard that oral or injected
>testosterone does nothing for penis size (in adults)... but I've never
>heard about the possible effects of a topically applied solution.
>
>I'm almost sure that there are ways of obtaining Androgel... if not
>directly from a physician, then probably off of the internet.
>
>If you decide to experiment with this, please let me know. I'd be very
>interested in hearing about your findings
>
>BA
>
>
>>From: "Ken Reicher"
>>To: Big Al
>>Subject: ?Androgel + Penis Enlargement
>>Date: Mon, 06 Aug 2001 20:47:51 -0700
>>
>>Hey Al,
>>VasoDerm may be "helpful" for Penis Enlargement, but can anybody confirm or shed some
>>light on some info. I just got at my gym about Androgel and its effects
to >>CAUSE Penis Enlargement.
>>I was in the shower, yeah it is a straight gym, and this middle aged man
>>waltzes in ... humming a really happy tune ... I glance at his crotch and
>>notice he is nicely hung. I asked him if he used any supplements to "help
>>him out with strength training" ... he grabbed his cock and asked me,
"you
>>mean skeletal or love muscle"?
>>Since he broke the ice, I asked if he did any form of Penis Enlargement. He said that
>>all he asked his doctor for was something to enhance LIBIDO. He was given
>>Androgel (RX only) and was intrigued by the instructions ... they
>>indicated to NOT put it on the penis. He asked the doctor why and he
>>casually remarked ... "maybe they are afraid of enlarging it". So he
>>"broke the rules" and started using it every other day on the penis and
>>every other day on the arms or abs ... within two months he had gained an
>>inch (both erect and limp).
>>Is this possible? Would a doctor prescribe this to a younger man? The
>>guy is really muscular so I suppose it helps both the penis and other
>>areas of manliness.
>>I've noticed ads that sound like Testosterone Gel, but would prefer the
>>REAL thing. Just want to get some feedback before pumping my family doc
>>for some LIBIDO help!
>>KR

The anabolic steroid Trenbolone acetate by itself increase hepatic IGF-1 levels by 150%. All androgens increase IGF-1 levels so the same argument can be said about any androgen. The only studies that show IGF-1 linked to cancer are ones that people had existing prostate and/or breast cancer and their was increased growth. In breast cancer its logical that there is increased IGF-1 since there is also an increase in estrogen. The only other explanation is that since IGF-1 can cause hyperplasia, you have an increased chance of new cells being cancerous. But that is really random chance just like mutations and the creation and death of new cells happens regardless. There is no direct connection.

Bottom line, don't take steroids or GH, or IGF-1 if you have cancer. You have bigger fish to fry.

http://www.lef.org/magazine/mag2004/mar2004_cover_dhea_02.htm

Stephen Cherniske: First of all, the widely cited association between IGF-1 and prostate cancer has been debunked.106,107 That said, the concern for tumor acceleration does make sense because IGF has angiogenic activity that would favor tumor growth. But IGF-1 has only been shown to accelerate tumor growth in test tubes. Test tubes and petri dishes do not have immune systems, which are upregulated by IGF-1. In fact, the preponderance of the evidence shows that IGF-1 does not promote cancer in any living organism, whether animal or human. Even direct injection of IGF-1 does not promote tumor growth in animals.108 In Europe, IGF-1 is routinely given to cancer patients to help them gain weight.

Aside from this, it is important to note that increases in IGF-1 after DHEA supplementation are significant but modest, and there are no published studies in which DHEA administration caused IGF-1 to rise above the normal range. Moreover, scores of published studies demonstrate the essential role that IGF-1 plays in the repair and regeneration of the brain, skeleton, and cardiovascular and immune systems.109-112 Conversely, low IGF-1 levels have been associated with dementia, atherosclerosis, osteoporosis, and sarcopenia,54,113 and a study in the journal Gerontology shows that men who maintain youthful levels of IGF-1 do not experience the decline in testosterone or muscle mass, or the accumulation of fat, that has been considered an inevitable consequence of aging.114

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There are many cancers that feed off of IGF1. Colon cancer is one such cancer. Prostate cancer, at least according to studies, is another such cancer. The IGF1 doesn't cause the cancer, it just makes it grow faster.

dragon said:

Yes, but the suppliment L-Arginine will also raise it. The question is how much would L-arginine along with weight or isometric exercise (to increase testosterone) raise HGH? ...

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Where did you find that arginine raises test??? It does not from my understanding of the compound. Arginine is a vasodilator not a testosterone booster. What it does is raise nitrous oxide levels in the body. This helps to get more blood to the tissues resulting in more intense pumps when working out and should also help get firmer erections similar to how Viagra (another vasodilator) does.

Good reading :D

sikdogg said:

Where did you find that arginine raises test??? It does not from my understanding of the compound. Arginine is a vasodilator not a testosterone booster. What it does is raise nitrous oxide levels in the body. This helps to get more blood to the tissues resulting in more intense pumps when working out and should also help get firmer erections similar to how Viagra (another vasodilator) does.

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Larginine does not raise testosterone directly...it allows for more natural HGH to be produced in the body which in turn allows less DHT to be produced and this indirectly keeps testosterone at higher levels in the body...weight/resistance exercise increases testosterone (herbs like tribulus also increases testosterone)...I was talking about two separate things...

Arginine can but not very effective by itself. It is believed that it works better in combination with Lysine and Ornithine. Alone they do not increase GH levels from oral consumption. Ornithine does not induce GH release even intravensouly. The studies showing any GH release from individual aminos is from intravenous administration or in old men (effect not shown in young men).

The only combination that has been shown to work with oral doses in young men during basal conditions is arginine/lysine. Although certain combo's definitely have biological activity, Arginine has been shown to inhibit the reduction of GH due to increased IGF-1 levels. In terms of growth it would be mostly indirect by reducing catabolic/proteolysis activity. It also helps with blood glucose and nutrient partioning and also increased lipolysis.

Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men.

Suminski RR, Robertson RJ, Goss FL, Arslanian S, Kang J, DaSilva S, Utter AC, Metz KF.

Human Performance Laboratory, University of Houston, TX 77204, USA.

Sixteen men completed four trials at random as follows: (Trial A) performance of a single bout of resistance exercise preceded by placebo ingestion (vitamin C); (Trial B) ingestion of 1,500 mg L-arginine and 1,500 mg L-lysine, immediately followed by exercise as in Trial A; (Trial C) ingestion of amino acids as in Trial B and no exercise; (Trial D) placebo ingestion and no exercise. Growth hormone (GH) concentrations were higher at 30, 60, and 90 min during the exercise trials (A and B) compared with the resting trials (C and D) (p < .05). No differences were noted in [GH] between the exercise trials. [GH] was significantly elevated during resting conditions 60 min after amino acid ingestion compared with the placebo trial. It was concluded that ingestion of 1,500 mg arginine and 1,500 mg lysine immediately before resistance exercise does not alter exercise-induced changes in [GH] in young men. However, when the same amino acid mixture is ingested under basal conditions, the acute secretion of GH is increased.

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Current Medical Research & Opinion

Vol. 7, No. 7, 1981

A. Isidori M.D. A. Lo Monaco, M.D.& M. Cappa, M.D.
Medical Clinic V. University of Rome, Rome, Italy. Received: 13th March 1981

Summary

A study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. the results showed that oral administration of a combination of two amino acids (1200 mg l-lysine plus 1200 mg l-arginine pyroglutanate) provoked a release of pituitary somatotrophin & insulin. This phenomenon was reproducible & the growth hormone secreted in response to this stimulation had biological activity (as demonstrated by radiorecepter assay & somatomedin induction). The effect appeared to be specific to the combination of the two amino acids; neither of the amino acids demonstrated appreciable stimulating activity when administered alone, even at the same doses.

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There is also another intersting study in whic ARG blunted the inhibitory effect of IGF-1 on GH release

Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans.

Gianotti L, Maccario M, Lanfranco F, Ramunni J, Di Vito L, Grottoli S, Muller EE, Ghigo E, Arvat E.

Department of Internal Medicine, University of Turin, Italy.

Insulin-like growth factor I (IGF-I) exerts a negative feedback effect on GH secretion via either direct actions at the pituitary level or indirect ones at the hypothalamic level, through stimulation of somatostatin (SS) and/or inhibition of GHRH release. In fact, recombinant human IGF-I (rhIGF-I) in humans inhibits spontaneous GH secretion as well as the GH response to GHRH and even more to GH/GH-releasing peptides, whose main action is on the hypothalamus, antagonizing SS and enhancing GHRH activity. The aim of the present study was to further clarify in humans the mechanisms underlying IGF-I-induced inhibition of somatotroph secretion. In six normal young volunteers (all women; mean +/- SEM: age, 28.3+/-1.2 yr; body mass index, 21.3+/-1.2 kg/m2) we studied the GH response to GHRH (1 microg/kg, iv, at 0 min), both alone and combined with arginine (ARG; 0.5 g/kg, iv, from 0-30 min), which probably acts via inhibition of hypothalamic SS release, after pretreatment with rhIGF-I (20 microg/kg, sc, at -180 min) or placebo. rhIGF-I increased circulating IGF-I levels (peak at -60 vs. -180 min: 54.9+/-3.9 vs. 35.9+/-3.3 mmol/L; P < 0.05) to a reproducible extent, and these levels remained stable and within the normal range until 90 min. The mean GH concentration over 3 h (from -180 to 0 min) before ARG and/or GHRH was not modified by placebo or rhIGF-I. After placebo, the GH response to GHRH (peak, 23.6+/-2.9 microg/L) was strikingly enhanced (P < 0.05) by ARG coadministration (69.6+/-9.9 microg/L). rhIGF-I blunted the GH response to GHRH (13.1+/-4.5 microg/L; P < 0.05), whereas that to GHRH plus ARG was not modified (59.5+/-8.9 microg/L), although it occurred with some delay. Mean glucose and insulin concentrations were not modified by either placebo or rhIGF-I. In conclusion, ARG counteracts the inhibitory effect of rhIGF-I on somatotroph responsiveness to GHRH in humans. These findings suggest that the acute inhibitory effect of rhIGF-I on the GH response to GHRH takes place on the hypothalamus, possibly via enhancement of SS release, and that ARG overrides this action.

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dragon said:

...weight/resistance exercise increases testosterone (herbs like tribulus also increases testosterone)...

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Herbs used to raised test has been somewhat hit or miss. Some claim good results while others get nothing from them. It can't hurt to try them but i wouldn't place too much hope on them. I'd also like to add that any result from natural supps like trib, ZMA, TongKat Ali and all the other are marginal at best. If they did i fact raise test levels, i doubt that it would raise it above the upper limits of normal test level otherwise you would most likely get HPTA suppression.

I wonder if you use these injections for an extended period of time won't they cause your body's natural production to slow/stop? also what's the point can't you just makes gains over time and be happy with that, Why do you have to gain so fast and how do you know it works in humans for Penis Enlargement anyway?

Straight8 said:

also what's the point can't you just makes gains over time and be happy with that, Why do you have to gain so fast and how do you know it works in humans for Penis Enlargement anyway?

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You really want to be Penis Enlargement'ing, an hour a day for the next 10 years?
If it came down some injections, or 3,000 hours of Penis Enlargement, what would you pick?

Straight8 said:

I wonder if you use these injections for an extended period of time won't they cause your body's natural production to slow/stop?

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Yes if you inject hormones in your body, your body will stop producing those same hormones but depending on which hormones you inject, recovery after is very quick. IGF and HGH rebound very quickly typically within a wek or two. Testosterone can take some time to recover depending on how long your therapy was. Test suppression can be minimized and recovery accelerated by using propper post cycle therapy and HCG during the cycle.

...also what's the point can't you just makes gains over time and be happy with that, Why do you have to gain so fast and how do you know it works in humans for Penis Enlargement anyway?

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As Ulcasterdropout explained, the ability to accelerate gains is great as it will allow us to achieve our goals sooner than later. I'd rather have a big dick now as opposed to next year or the year after.

We know from studies that exogenous applications of certain hormones do in fact work on certain types of human tissues. We know that testosterone WILL help to increase muscle size, we know that HGH/IGF-1 WILL decrease bodyfat and increase lean body mass, We know that mystatin anti-bodies WILL increase lean body mass, but what we're not sure of is if these same hormones/polypeptides will do the same for our penis'. That is where the study that Big Al posted comes into play. That study has shown that IGF/HGH has been effective in increasing penile tissue in mice. Yes' i know that we aren't mice but none the less this study is encouraging as we now know that it is possible to increase penis size thru hormone therapy (as alot of people have theorized). Now, it's just a matter of testing this out on humans.

... another interesting point about the rat study is that young rats experienced much better gains than the older rats.

Negative posted: "I think its very strange Big Al post this article when saying on his page " How you can permanently add as much as 2 extra inches to your penis in just weeks." Why take hormons when you can gain 2 inch in weeks ? He he...

And this "Doctor" Dr. Reicher most be a great source *LOL*"

And your point is? I personally DON'T recommend injecting/ingesting any hormones....I merely posted this for informational purposes. I don't necessarily agree with everything that Dr. Reicher says, but he is a very intelligent doctor that has helped many of our members with their medical questions.

No offense intended, but you strike me as one of those individuals that try to seem intelligent by using sarcasm as opposed to actually using facts or theories. If you have information that somehow disproves what the studies have shown, please post it here.