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"A Warning on IGF-1/RL3"
#1
I'm unbias on IGF but I did find an interesting article.


posted by buffness on SBI


You be the judge, their will always be two sides to a story. It's up to you to pick which one is right for you....

By Cy Willson.....

IGF-1: Worst Bodybuilding Drug Ever?

Q: What ever happened to IGF-1? It was talked about in 'roid books in the early '90s but you don't hear much about it now, except for a few sleazy supplement companies who are using the name.

A: IGF-1 can allow for hypertrophy of muscle. Will it do such a thing when administered to humans? Yes. However, the gains seen really aren’t spectacular. More often than not, they don’t even come close to gains seen using androgens.

For the most part, people should realize that IGF-1 is primarily responsible for GH’s anabolic effects in skeletal muscle as well as cell proliferation, leading to enlarged internal organs and increasing the risk for cancer dramatically. Oh, and this most certainly includes Long R3 IGF-I as I know some people will try to argue that it's much safer.

Well, in order to give you the total picture, I’m going to go over some basic molecular biology as well as list the direct evidence we have concerning the side effects of IGF-1 and yes, that includes Long R3 IGF-I.

First, people should understand that in the human cell cycle, growth requires growth factors in general. Seems simple enough. The next thing people need to understand is that for a normal cell, death is something that'll inevitably occur via loss of telomerase or apoptosis (programmed cell death). Again, I can’t overemphasize enough that the default pathway in humans is death, not growth. (Reassuring, isn't it?)

Now, when you hear of cancer, malignant cancer, people tend to think of uncontrolled cell division. Essentially though, these transformed cancerous cells are immortalized. Now, many changes are required for this to occur (i.e. increased telomerase, increased bcl-2, increased myc and decreased p53). In the development of cancer, we tend to think of carcingogens consisting of both initiators and promoters. For instance, some initiators are UV radiation and tobacco smoke, usually causing DNA damage or mutation, whereas promoters tend to stimulate cell division. A few examples are phorbol esters, hormones (e.g. estrogens) and yes, growth factors.

Now, keep in mind both events, initiation and promotion, are required for the development of malignant cells. As a side note, viral infection can also lead to the two events, but I digress. Anyhow, normally a cell serves its purpose and then dies via apoptosis. However, malignant cells don’t undergo apoptosis. They are, as I said before, immortal. The normal triggers to apoptosis are DNA damage, loss of cell-matrix contact, loss of cell to cell contact, and last but most certainly not least, lack of growth factors.

When you introduce growth factors, you’re providing the catalyst for cancer formation, so to speak. Let’s say, for instance, you get many sunburns during your lifetime. Now, let’s say that one cell has its DNA damaged or altered. This, in and of itself, isn’t too much of a concern as this is only one part of the equation, the iniation. The second part is the promoter (including growth factors).

Well, let’s imagine we introduce growth factors to the cell which has damaged or mutated DNA and it then begins to divide at a more and more rapid rate until it won’t stop. Voila, you have a tumor, which is now capable of even faster growth as well as being invasive (able to invade surrounding tissues) and metastatic (able to cause growth in completely unrelated and distant tissues) in regard to other tissues.

In other words, you now have a malignant tumor, which we commonly refer to as cancer. The fact is, cancer stems from just one cell, just one cell, which begins to divide uncontrollably. People often talk about GH and the side effects thereof, but what most don’t realize is that many of those side effects aren't necessarily mediated by growth hormone but by IGF-1.

Many people may go their whole lives with some DNA damage (or mutation rather) and never have cancer, but with the addition of growth factors, you’re asking for trouble. Even more specifically, you can increase the risk of developing rare forms of cancer, like sarcomas, which are tumors commonly found in connective tissues (i.e. muscle, bone, cartilage, etc.)

Okay, now on to the more cosmetic side effects. With Long R3 IGF-I, it was shown to stimulate growth of the gastrointestinal tract. IGF-1 actually had no effect on body weight and wet tissue weight of the small and large intestine, whereas Long R3 IGF-I resulted in a 20% increase in the weight of the small and large intestine. This is what's causing a "GH gut" although using Long R3 IGF-I is much, much worse than using GH.

Something else to keep in mind is that Long R3 IGF-I was shown to be even more potent than IGF-1 in inhibiting apoptosis and thus its potential for causing cancer is many times greater.

Another idea is that IGF-1 may also keep telomerase activity high, which as we noted previously is a contributing factor for the loss of regulation in terms of cell division. In other words, it again can substantially increase the risk for developing cancer. Long R3 IGF-I was shown to increase telomerase activity in human prostate cancer cells, whereas IGF-1 had no effect.

So, when I tell you to stay away from IGF-1, I’m actually referring to Long R3 IGF-I as it’s what's most commonly circulated and used. Although both aren't something a person should use, Long R3 IGF-1 is probably the worst choice you can make.

So, unless you’re an IFBB pro who consistently places in the top ten at popular contests, you should forget about using IGF-1, or specifically the analogue of IGF-1 called Long R3 IGF-I. It’s really not worth the risk. This, out of all the compounds that bodybuilders may use, is probably the worst in terms of potential side effects.

If you want a true distended belly and increased risk of cancer, be my guest. (47-52)

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16. Hermann R, Niebch G, Borbe HO et al: Enantioselective pharmacokinetics and bioavailability of different racemic alpha-lipoic acid formulations in healthy volunteers. Eur J Pharm Sci 1996; 4:167-174

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19. Streeper RS, Henriksen EJ, Jacob S et al: Differential effects of lipoic acid steroisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol 1997; 273(1 pt 1):E185-E191

20. Khamaisi M, Potashnik R, Tirosh A et al: Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats. Metabolism 1997; 46(7):763-768

21. Henriksen EJ, Jacob S, Streeper RS et al: Stimulated by alpha-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats. Life Sci 1997; 61(8):805-812

22. Wickramasinghe SN & Hasan R: In vitro effects of vitamin C, thioctic acid and dihydrolipoic acid on the cytotoxicity of post-ethanol serum. Biochem Pharmacol 1992; 43(3):407-411

23. Dimpfel W, Spueler M, Pierau F-K et al: Thioctic acid induces dose-dependent sprouting of neurites in cultured rat neuroblastoma cells. Dev Pharmacol Ther 1990; 14(3):193-199

24. Prehn JHydromax, Karkoutly C, Nuglisch J et al: Dihyrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992; 12(1):78-87

25. Burkart V, Koike T, Brenner HH et al: Dihydrolipoic acid protects pancreatic islet cells from inflammatory attack. Agents Actions 1993; 38(1-2):60-65

26. Bauer A, Harrer T, Peukert M et al: Alpha-lipoic acid is an effective inhibitor of human immuno-deficiency Virus (HIV-1) replication. Klin Wochenschr 1991; 69(15):722-724

27. Suzuki YJ, Aggarwal BB & Packer L: alpha-Lipoic acid is a potent inhibitor of NF-kappaB activation in human T cells. Biochem Biophys Res Commun 1992; 189(3):1709-1715

28. Bierhaus A, Chevion S, Chevion M et al: Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 1997; 46(9):1481-1490

29. Constantinescu A, Tritschler H & Packer L: alpha-Lipoic acid protects against hemolysis of human erythrocytes induced by peroxyl radicals. Biochem Mol Biol Int 1994; 33(4):669-679

30. Greene EL, Nelson BA, Robinson KA, Buse MG. "alpha-Lipoic acid prevents the development of glucose-induced insulin resistance in 3T3-L1 adipocytes and accelerates the decline in immunoreactive insulin during cell incubation." Metabolism 2001 Sep;50(9):1063-9

31. Maddux BA, et al. "Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid." Diabetes 2001 Feb;50(2):404-10

32. Weinstein RB, Tritschler HJ, Henriksen EJ. "Antioxidant alpha-lipoic acid and protein turnover in insulin-resistant rat muscle." Free Radic Biol Med 2001 Feb 15;30(4):383-8

33. Yaworsky K, Somwar R, Ramlal T, Tritschler HJ, Klip A. "Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes." Diabetologia 2000 Mar;43(3):294-303

34. Jacob S, et al. "Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial." Free Radic Biol Med 1999 Aug;27(3-4):309-14

35. Estrada DE, et al. "Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway." Diabetes 1996 Dec;45(12):1798-804

36. Hundal RS, et al. "Mechanism by which metformin reduces glucose production in type 2 diabetes." Diabetes 2000 Dec;49(12):2063-9

37. Anderwald C, et al. "Inhibition of glucose production and stimulation of bile flow by R (+)-alpha-lipoic acid enantiomer in rat liver." Liver 2002 Aug;22(4):355-62

38. Saengsirisuwan V, Perez FR, Kinnick TR, Henriksen EJ. "Effects of exercise training and antioxidant R-ALA on glucose transport in insulin-sensitive rat skeletal muscle." J Appl Physiol 2002 Jan;92(1):50-8

39. Evans JL, Goldfine ID. "Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes." Diabetes Technol Ther 2000 Autumn;2(3):401-13

40. Saengsirisuwan V, Kinnick TR, ScHydromaxit MB, Henriksen EJ. "Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats." J Appl Physiol 2001 Jul;91(1):145-53

41. Konrad T. "alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes." Diabetes Care 1999 Feb;22(2):280-7

42. Jacob S, et al. "Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid." Arzneimittelforschung 1995 Aug;45(8):872-4

43. Jacob S, Rett K, Henriksen EJ, Haring HU. "Thioctic acid—effects on insulin sensitivity and glucose-metabolism." Biofactors 1999;10(2-3):169-74

44. Jacob S, Henriksen EJ, Tritschler HJ, Augustin HJ, Dietze GJ. "Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid." Exp Clin Endocrinol Diabetes 1996;104(3):284-8

45. Bigsby RM, Caperell-Grant A, Madhukar BV. "Xenobiotics released from fat during fasting produce estrogenic effects in ovariectomized mice." Cancer Res. 1997 Mar 1;57(5):865-9

46. McCurdy CE, Davidson RT, Cartee GD. "Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle." Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E693-E700.

47. Steeb CB, Trahair JF, Read LC. "Administration of insulin-like growth factor-I (IGF-I) peptides for three days stimulates proliferation of the small intestinal epithelium in rats." Gut. 1995 Nov;37(5):630-8

48. Wetterau LA, Francis MJ, Ma L, Cohen P. "Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells." J Clin Endocrinol Metab. 2003 Jul;88(7):3354-9

49. Devi GR, Graham DL, Oh Y, Rosenfeld RG. "Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling." Growth Horm IGF Res. 2001 Aug;11(4):231-9

50. Nickerson T, Huynh H, Pollak M. "Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cells." Biochem Biophys Res Commun. 1997 Aug 28;237(3):690-3

51. Vink-van Wijngaarden T, Pols HA, Buurman CJ, Birkenhager JC, van Leeuwen JP. "Inhibition of insulin- and insulin-like growth factor-I-stimulated growth of human breast cancer cells by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogue EB1089." Eur J Cancer. 1996 May;32A(5):842-8

52. Wetterau LA, Francis MJ, Ma L, Cohen P. "Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells." J Clin Endocrinol Metab. 2003 Jul;88(7):3354-9
 

Super

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"A Warning on IGF-1/RL3"
#3
Great Post! Now I am going to take twice the amount that I was normally take! have bumped it from 20mcg's to 40-50mcg's a day.

Thanks for the post man, but I already knew all of these sides, and I do not get any! Cheers!

Yum, IGF!
 
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"A Warning on IGF-1/RL3"
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The caveat to cancer is that increasing the telomeres in a cell will basically decrease the age of the cell. Aging is not that well understood but what is known is that telomeres are one of the most significant biomarkers for aging.

So increasing the telomeres in your cells is probably not a bad thing at all and one reason why some people in the past mistakenly called HGH the new "Fountain of Youth".

The problem of course is cancer in that not only are cancer cells immortal, but they are greedy as well and also have been mutated to keep dividing as if a permanent growth factor has been induced on them whereas fat cells for example generally only divide once they have been fully saturated with lipids.

So yah it is a double edged sword. Of course, even if you lengthen the telomeres on your cells it won't do anything for repeated DNA damage done to your body over time which effectively mutates the genetic code in each individual cell (if things get too fucked up then apoptosis occurs).

Anyways, I think we are probably about 20 years or less away from having anti-aging therapies which for the most part will make humans rich enough to take advantage of them that for all practical purposes will make them immortal.

When and if that day happens it will be a scary day for mankind for some very common sense reasons you can probably come up with when you have a whole planet of people who do not age, yet still have children. In effect, humanity itself at that point will become a cancer to the planet sucking up all the available resources until everything dies all at once.
 
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"A Warning on IGF-1/RL3"
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He could disembowel himself or else march an army of angry Scottsman to invade England like William Wallace did before he got the intestine treatment.
 
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"A Warning on IGF-1/RL3"
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Supra said:
Great Post! Now I am going to take twice the amount that I was normally take! have bumped it from 20mcg's to 40-50mcg's a day.

Thanks for the post man, but I already knew all of these sides, and I do not get any! Cheers!

Yum, IGF!
This is supras way of using humor to block out all of those horrible side effects and forget about them. lol
 
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"A Warning on IGF-1/RL3"
#10
This kind of information worries me. I mean does anybody know whethere Penis Enlargement:ing is dangerous in the long run? Nobody has gotten dickcanser from it yet anyhow....
 

Super

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"A Warning on IGF-1/RL3"
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Well considering I am the only one who is taking it, that would be a no!
 
T

TheExecutioner

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"A Warning on IGF-1/RL3"
#12
Hope nothing bad happens to you Supra, youd be a great loss to the Penis Enlargement Community and your buddies :(
 
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"A Warning on IGF-1/RL3"
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Yes, IGF-1/GH can "SPenis EnlargementED UP" cancerous cell's/tumor growth's (that you already have), but clinical studies have already shown that IGF-1/GH will not cause cancer/tumor's to grow out of nowhere... So, if you've had cancer or a tumor growth in the past...or cancer run's rampant in your family, then IGF-1/GH are probably not a very good idea...also if you're a smoker/chewer...

As far as the side-effect's of the "enlarged intestine's/gut"...side-effect's such as those and acromegaly are only present in the more "extreme" bodybuilder's...because of the amount's of "drug's" taken and the duration of the cylcle's...

Now, I'm not saying that their are'nt risk's with growth factor's, but they alway's tend to be over-hyped and misleading... My brother-in-law is a former bodybuilder, so I've been around alot of this stuff and researched alot, as well as taking IGF-1LR3 and a few other Anabolic's/Androgen's, and I can tell you first hand, that the side-effect's are "over-hyped"... that's not to say that their aren't any risk's...and it's possible that an already present cancerous cell can be speed up into a potentially lethal cancer, but the chance's are pretty small...

I just want to make clear, that I am not endorsing IGF-1 or any other "reseachable" drug... (except maybe cialis, wich is a wonderful Penis Enlargement aid, I might add)... and that's why I won't put source's here in the forum or try and push anybody into using these "substances"... Use these "drug's" at your own risk!

Peace
 
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"A Warning on IGF-1/RL3"
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SLICEDBEEF said:
...or cancer run's rampant in your family, then IGF-1/GH are probably not a very good idea...

My families got a bad case of that problem. Hopefully I dont get cancer... :(
 
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"A Warning on IGF-1/RL3"
#16
or smoke...or chew...or drink "alot"...or anyother thing that may be detrimental to your health...
 
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"A Warning on IGF-1/RL3"
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SLICEDBEEF said:
Yes, IGF-1/GH can "SPenis EnlargementED UP" cancerous cell's/tumor growth's (that you already have), but clinical studies have already shown that IGF-1/GH will not cause cancer/tumor's to grow out of nowhere... So, if you've had cancer or a tumor growth in the past...or cancer run's rampant in your family, then IGF-1/GH are probably not a very good idea...also if you're a smoker/chewer...

As far as the side-effect's of the "enlarged intestine's/gut"...side-effect's such as those and acromegaly are only present in the more "extreme" bodybuilder's...because of the amount's of "drug's" taken and the duration of the cylcle's...

Now, I'm not saying that their are'nt risk's with growth factor's, but they alway's tend to be over-hyped and misleading... My brother-in-law is a former bodybuilder, so I've been around alot of this stuff and researched alot, as well as taking IGF-1LR3 and a few other Anabolic's/Androgen's, and I can tell you first hand, that the side-effect's are "over-hyped"... that's not to say that their aren't any risk's...and it's possible that an already present cancerous cell can be speed up into a potentially lethal cancer, but the chance's are pretty small...

I just want to make clear, that I am not endorsing IGF-1 or any other "reseachable" drug... (except maybe cialis, wich is a wonderful Penis Enlargement aid, I might add)... and that's why I won't put source's here in the forum or try and push anybody into using these "substances"... Use these "drug's" at your own risk!

Peace
I agree in a healthy individual even if they do develop a cancer cell the body just destroys it. Its why we see people like older people or sick people getting cancer like crazy. In fact thousands of times per day cancer cells are mutating into existence and your body is killing them off.

I think his argument in this article is sort of retarded. Basicaly hes saying don't take growth factors because the cancer cells will grow too. But he also says that the cancer cells have perma growth in them anyway because of mutations. So wouldn't growth factors balance it more with that logic? Which is flawed anyway.

The one part that was interesting however was where he mentioned that IGF develops the inner skeletal muscles. For example organs.
 

REDZULU2003

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"A Warning on IGF-1/RL3"
#19
I aint takeing this IGF shit, better IMHO to sticking with Ciallis and/or Muira Puima , both work great in pe and bodybuilding.

I have cancer in my family but mainly on the woman side ... I however dont smoke nor drink much, but when I drink I DRINK lol but fuck it, I gotta enjoy myself right.
 

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